slc34a2a solute carrier family 34 member 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc34a2aprovided by ZNC
Official Full Name: solute carrier family 34 member 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000524-1
See related: Ensembl:ENSDARG00000012903 AllianceGenome:ZFIN:ZDB-GENE-000524-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: npt2b; NaPi-II; slc34a2; NaPi-IIb1; wu:fb63d07
Summary: Enables high-affinity phosphate:sodium symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane. Is expressed in digestive system duct; endoderm; enterocyte; and kidney. Human ortholog(s) of this gene implicated in pulmonary alveolar microlithiasis. Orthologous to human SLC34A2 (solute carrier family 34 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (14432438..14442899)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (13745925..13756386)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish NaPi-IIb1 is likely the transport protein that is responsible for arsenic accumulation in vivo
Title: Pentavalent arsenate transport by zebrafish phosphate transporter NaPi-IIb1.
Sense/antisense RNAs of an evolutionarily conserved phosphate transporter gene (Slc34a2a) are coexpressed in a short time window during embryonic development of zebrafish.
Title: Processing of naturally occurring sense/antisense transcripts of the vertebrate Slc34a gene into short RNAs.
The endogenous transcript for maintaining phosphate (Pi) homeostasis has been identified, cloned and characterized. The transcript lacks an open reading frame and appears in different splice forms.
Title: Regulation of the NPT gene by a naturally occurring antisense transcript.

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General gene information

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Markers

z1705 (e-PCR), detects polymorphism
- UniSTS:205144

fb63d07 (e-PCR)
- UniSTS:189037

G45117 (e-PCR)
- UniSTS:105919

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables high-affinity phosphate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:phosphate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	IDA Inferred from Direct Assay more info
enables sodium:phosphate symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular phosphate ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphate ion transport	IDA Inferred from Direct Assay more info
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 34 member 2a

Names: Na/Pi cotransport system protein, type II; solute carrier family 34 (sodium phosphate), member 2a; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131624.1 → NP_571699.1 solute carrier family 34 member 2a

See identical proteins and their annotated locations for NP_571699.1

Status: PROVISIONAL

Source sequence(s)

AF121796

UniProtKB/TrEMBL

Q9PTQ8

Related

ENSDARP00000023797.8, ENSDART00000024328.9

Conserved Domains (2) summary

TIGR01013
Location:79 → 566

2a58; Phosphate:Na+ Symporter (PNaS) Family

pfam02690
Location:373 → 511

Na_Pi_cotrans; Na+/Pi-cotransporter