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fgfr3 fibroblast growth factor receptor 3 [ Danio rerio (zebrafish) ]

Gene ID: 58129, updated on 24-Nov-2024

Summary

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Official Symbol
fgfr3provided by ZNC
Official Full Name
fibroblast growth factor receptor 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-000816-1
See related
Ensembl:ENSDARG00000004782 AllianceGenome:ZFIN:ZDB-GENE-000816-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc27h01; sb:eu563; wu:fc27h01
Summary
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including fin bud; gut; head; nervous system; and neural rod. Used to study camptodactyly-tall stature-scoliosis-hearing loss syndrome. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See fgfr3 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13213566..13294872, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (13081091..13163841, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene uncharacterized LOC108191973 Neighboring gene uncharacterized LOC108191974

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. fgfr3 and regionalization of anterior neural tube in zebrafish. Sleptsova-Friedrich I, et al. Mech Dev, 2001 Apr. PMID 11287195
  2. Identification of a novel insertion mutation in FGFR3 that causes thanatophoric dysplasia type 1. Lindy AS, et al. Am J Med Genet A, 2016 Jun. PMID 27028100
  3. The expression of fgfr3 in the zebrafish head. Ledwon JK, et al. Gene Expr Patterns, 2018 Sep. PMID 29630949
  4. Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders. Aksoy I, et al. Hum Mol Genet, 2017 Jan 15. PMID 28365779
  5. Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish. Goldshmit Y, et al. Neural Dev, 2018 Nov 17. PMID 30447699, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/beta-catenin signaling.
    Title: Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling.
  2. Zebrafish FGFR3 is a negative regulator of interferon (IFN) production in the innate immune response by suppressing the activity of TANK-binding kinase 1 (TBK1) in the process of virus infection.
    Title: Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.
  3. Study revealed spatial and temporal distribution of fgfr3 transcript in chondrocytes of the head cartilages, osteoblasts involved in bone formation, ventricular zone of the brain, undifferentiated mesenchymal cells of the skin, and lens epithelium of the eye.
    Title: The expression of fgfr3 in the zebrafish head.
  4. Leg1 plays a unique role in protecting liver development under different stress conditions by serving as a secreted signaling molecule/modulator.
    Title: Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor 3
NP_571681.2
XP_009305459.1
XP_009305463.1
XP_017214284.1
XP_021336334.1
XP_068069026.1
XP_068069027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131606.2 → NP_571681.2  fibroblast growth factor receptor 3 precursor

    Status: VALIDATED

    Source sequence(s)
    CR556722, CR559942, CU694230, LO018146
    UniProtKB/Swiss-Prot
    Q9I8X3
    UniProtKB/TrEMBL
    A0A8M1PBP7, F1QPA0
    Related
    ENSDARP00000011898.9, ENSDART00000013534.9
    Conserved Domains (7) summary
    cd04974
    Location:280 → 369
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:173 → 257
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:466 → 799
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67 → 121
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:183 → 257
    IG; Immunoglobulin
    smart00410
    Location:272 → 368
    IG_like; Immunoglobulin like
    pfam07714
    Location:479 → 754
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    13213566..13294872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480659.2 → XP_021336334.1  fibroblast growth factor receptor 3 isoform X6

    UniProtKB/Swiss-Prot
    Q9I8X3
    UniProtKB/TrEMBL
    A0A8M9QFK2
    Conserved Domains (4) summary
    cd05857
    Location:168 → 252
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:275 → 364
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:462 → 795
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67 → 121
    IGc2; Immunoglobulin C-2 Type

  2. XM_009307188.4 → XP_009305463.1  fibroblast growth factor receptor 3 isoform X5

    UniProtKB/Swiss-Prot
    Q9I8X3
    UniProtKB/TrEMBL
    A0A8M3B533
    Conserved Domains (7) summary
    cd04974
    Location:276 → 365
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:169 → 253
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:463 → 796
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67 → 121
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:179 → 253
    IG; Immunoglobulin
    smart00410
    Location:268 → 364
    IG_like; Immunoglobulin like
    pfam07714
    Location:476 → 751
    Pkinase_Tyr; Protein tyrosine kinase

  3. XM_068212925.1 → XP_068069026.1  fibroblast growth factor receptor 3 isoform X3

  4. XM_068212926.1 → XP_068069027.1  fibroblast growth factor receptor 3 isoform X4

  5. XM_017358795.3 → XP_017214284.1  fibroblast growth factor receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9I8X3
    UniProtKB/TrEMBL
    A0A8M6Z1R4

  6. XM_009307184.4 → XP_009305459.1  fibroblast growth factor receptor 3 isoform X2

    UniProtKB/Swiss-Prot
    Q9I8X3
    UniProtKB/TrEMBL
    A0A8M3B7V7
    Conserved Domains (7) summary
    cd04974
    Location:280 → 367
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:173 → 257
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:467 → 800
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67 → 121
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:183 → 257
    IG; Immunoglobulin
    smart00410
    Location:272 → 367
    IG_like; Immunoglobulin like
    pfam07714
    Location:480 → 755
    Pkinase_Tyr; Protein tyrosine kinase

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395307.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    270317..294997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I8X3.1 GenPept UniProtKB/Swiss-Prot:Q9I8X3

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