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fth1a ferritin, heavy polypeptide 1a [ Danio rerio (zebrafish) ]

Gene ID: 58108, updated on 2-Nov-2024

Summary

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Official Symbol
fth1aprovided by ZNC
Official Full Name
ferritin, heavy polypeptide 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000831-2
See related
Ensembl:ENSDARG00000015551 AllianceGenome:ZFIN:ZDB-GENE-000831-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fth1; fb06g09; zeh1145; hm:zeh1145; wu:fb06g09; wu:fq18c10
Summary
Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to act upstream of or within intracellular iron ion homeostasis and iron ion transport. Predicted to be active in cytoplasm. Is expressed in blood; eye; liver; ovary; and testis. Human ortholog(s) of this gene implicated in hemochromatosis type 5 and neurodegeneration with brain iron accumulation. Orthologous to several human genes including FTH1 (ferritin heavy chain 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See fth1a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (12927944..12936708)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (12675210..12683988)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene gap junction protein delta 6 Neighboring gene SH3-domain GRB2-like 3a Neighboring gene serum amyloid A Neighboring gene ribosomal protein, large P2, like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fingerprinting fecal DNA and mRNA as a non-invasive strategy to assess the impact of polychlorinated biphenyl 126 exposure on zebrafish. Liu M, et al. J Environ Sci (China), 2021 Aug. PMID 34210431
  2. Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System. Badenetti L, et al. Int J Mol Sci, 2023 Apr 6. PMID 37047777, Free PMC Article
  3. Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. Usenko CY, et al. Toxicol Appl Pharmacol, 2008 May 15. PMID 18299140, Free PMC Article
  4. Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney. Zhang J, et al. PLoS Genet, 2018 Sep. PMID 30248094, Free PMC Article
  5. Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Groh KJ, et al. Fish Physiol Biochem, 2011 Sep. PMID 21229308, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric iron binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within iron ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ferritin, heavy polypeptide 1a
Names
ferritin, heavy polypeptide 1
NP_571660.1
XP_017212392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131585.1 → NP_571660.1  ferritin, heavy polypeptide 1a

    See identical proteins and their annotated locations for NP_571660.1

    Status: PROVISIONAL

    Source sequence(s)
    AF295373
    UniProtKB/TrEMBL
    A0A2R8QQC1, F6NRQ8, Q9DDT0
    Related
    ENSDARP00000026092.5, ENSDART00000027329.8
    Conserved Domains (2) summary
    cd01056
    Location:11 → 170
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:14 → 155
    Ferritin; Ferritin-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    12927944..12936708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356903.3 → XP_017212392.1  ferritin, heavy polypeptide 1a isoform X1

    UniProtKB/TrEMBL
    A0A2R8QQC1, F6NRQ8, Q9DDT0
    Conserved Domains (2) summary
    cd01056
    Location:11 → 170
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:14 → 155
    Ferritin; Ferritin-like domain
Nucleotide Protein Strain
Heading Accession and Version

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