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Usp29 ubiquitin specific peptidase 29 [ Mus musculus (house mouse) ]

Gene ID: 57775, updated on 27-Nov-2024

Summary

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Official Symbol
Usp29provided by MGI
Official Full Name
ubiquitin specific peptidase 29provided by MGI
Primary source
MGI:MGI:1888998
See related
Ensembl:ENSMUSG00000051527 AllianceGenome:MGI:1888998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ocat
Summary
Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of type I interferon-mediated signaling pathway; protein K48-linked deubiquitination; and protein stabilization. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; limb bud; testis; and trunk. Orthologous to human USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 4.9), whole brain E14.5 (RPKM 4.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Usp29 in Genome Data Viewer
Location:
7 A1; 7 4.04 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6733560..6970219)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6730559..6967220)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger, imprinted 1 Neighboring gene STARR-seq mESC enhancer starr_17985 Neighboring gene Peg3 opposite strand Neighboring gene paternally expressed 3 Neighboring gene Tctex1 domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17987 Neighboring gene STARR-seq mESC enhancer starr_17989 Neighboring gene microRNA 3099 Neighboring gene STARR-seq mESC enhancer starr_17990 Neighboring gene predicted gene, 53352 Neighboring gene zinc finger, imprinted 3 Neighboring gene STARR-seq mESC enhancer starr_17992 Neighboring gene zinc finger protein 264 Neighboring gene aurora kinase C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress. Wu Y, et al. Cell Death Dis, 2020 Sep 23. PMID 32968046, Free PMC Article
  2. The deubiquitinating gene Usp29 is dispensable for fertility in male mice. Huang Z, et al. Sci China Life Sci, 2019 Apr. PMID 30919279
  3. Transcriptional Truncation of the Long Coding Imprinted Gene Usp29. He H, et al. PLoS One, 2016. PMID 27327533, Free PMC Article
  4. Ocat, a paternally expressed gene closely linked and transcribed in the opposite direction to Peg3. Szeto IY, et al. Genomics, 2000 Jul 15. PMID 10903847
  5. Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription. Kim JD, et al. BMC Mol Biol, 2008 Dec 10. PMID 19068137, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-beta-activated kinase 1 deubiquitination.
    Title: Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination.
  2. Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
    Title: Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
  3. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
    Title: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
  4. USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress.
    Title: USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress.
  5. Ubiquitin-specific processing protease 29 (Usp29) shows predominant expression in mouse testis. Usp29 knockout mice (Usp29(-/-)) have normal fertility and show no detectable difference in the testis/body weight ratio, testicular and epididymal histology as well as epididymal sperm count from the wild-type littermates.
    Title: The deubiquitinating gene Usp29 is dispensable for fertility in male mice.
  6. The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease in growth rates for both males and females, while the mutants with biallelic expression of Peg3 and Usp29 resulted in an increased growth rate of female mice only
    Title: Allele and dosage specificity of the Peg3 imprinted domain.
  7. the transcription of Usp29 may be involved in DNA methylation setting of Zfp264 promoter in a sex-specific manner.
    Title: Transcriptional Truncation of the Long Coding Imprinted Gene Usp29.
  8. Conserved Sequence Element 2 (YY1 binding sites),functions as an activator for Peg3 transcription, while Conserved Sequence Element 1 acts as a repressor for the transcription of both Peg3 and Usp29.
    Title: Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 29
Names
ASL1/Usp29 fusion
deubiquitinating enzyme 29
ossification center-associated transcript
ubiquitin thioesterase 29
ubiquitin thiolesterase 29
ubiquitin-specific-processing protease 29
NP_001277923.1
NP_001347430.1
NP_001347431.1
NP_001407092.1
NP_001407093.1
NP_067298.2
XP_011248964.1
XP_017177905.1
XP_017177906.1
XP_030098699.1
XP_036009191.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290994.1 → NP_001277923.1  ubiquitin carboxyl-terminal hydrolase 29

    See identical proteins and their annotated locations for NP_001277923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC149277, AC157657
    Consensus CDS
    CCDS20784.1
    UniProtKB/Swiss-Prot
    C6EQG1, Q9ES63
    Related
    ENSMUSP00000143769.3, ENSMUST00000200535.6
    Conserved Domains (3) summary
    cd13312
    Location:4 → 109
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:290 → 540
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:763 → 823
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  2. NM_001360501.2 → NP_001347430.1  ubiquitin carboxyl-terminal hydrolase 29

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657
    Consensus CDS
    CCDS20784.1
    UniProtKB/Swiss-Prot
    C6EQG1, Q9ES63
    Conserved Domains (3) summary
    cd13312
    Location:4 → 109
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:290 → 540
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:763 → 823
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  3. NM_001360502.2 → NP_001347431.1  ubiquitin carboxyl-terminal hydrolase 29

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657
    Consensus CDS
    CCDS20784.1
    UniProtKB/Swiss-Prot
    C6EQG1, Q9ES63
    Conserved Domains (3) summary
    cd13312
    Location:4 → 109
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:290 → 540
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:763 → 823
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  4. NM_001420163.1 → NP_001407092.1  ubiquitin carboxyl-terminal hydrolase 29

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657
    UniProtKB/Swiss-Prot
    C6EQG1, Q9ES63

  5. NM_001420164.1 → NP_001407093.1  ubiquitin carboxyl-terminal hydrolase 29

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657
    UniProtKB/Swiss-Prot
    C6EQG1, Q9ES63

  6. NM_021323.4 → NP_067298.2  ubiquitin carboxyl-terminal hydrolase 29

    See identical proteins and their annotated locations for NP_067298.2

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657
    Consensus CDS
    CCDS20784.1
    UniProtKB/Swiss-Prot
    C6EQG1, Q9ES63
    Conserved Domains (3) summary
    cd13312
    Location:4 → 109
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:290 → 540
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:763 → 823
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. NR_153505.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657

  2. NR_153506.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657

  3. NR_153507.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157657
    Related
    ENSMUST00000207899.2

  4. NR_153590.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC157657, BC063090
    Related
    ENSMUST00000208662.2

  5. NR_185143.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657

  6. NR_185144.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657

  7. NR_185145.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657

  8. NR_185146.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149277, AC157657

  9. NR_185147.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157657

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    6733560..6970219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250662.3 → XP_011248964.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

    Conserved Domains (3) summary
    COG5207
    Location:297 → 830
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd13312
    Location:11 → 116
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:297 → 547
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_030242839.2 → XP_030098699.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

    Conserved Domains (3) summary
    COG5207
    Location:297 → 830
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd13312
    Location:11 → 116
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:297 → 547
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_017322416.2 → XP_017177905.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

    Conserved Domains (3) summary
    COG5207
    Location:297 → 830
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd13312
    Location:11 → 116
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:297 → 547
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. XM_017322417.2 → XP_017177906.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

    Conserved Domains (3) summary
    COG5207
    Location:297 → 830
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd13312
    Location:11 → 116
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:297 → 547
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. XM_036153298.1 → XP_036009191.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

    Related
    ENSMUSP00000143267.3, ENSMUST00000198068.3
    Conserved Domains (3) summary
    COG5207
    Location:297 → 830
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd13312
    Location:11 → 116
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:297 → 547
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES63.2 GenPept UniProtKB/Swiss-Prot:Q9ES63

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