Tbx21 T-box 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbx21provided by MGI
Official Full Name: T-box 21provided by MGI
Primary source: MGI:MGI:1888984
See related: Ensembl:ENSMUSG00000001444 AllianceGenome:MGI:1888984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TBT1; Tbet; Tblym
Summary: Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including T-helper 1 cell lineage commitment; negative regulation of T-helper 17 cell lineage commitment; and regulation of gene expression. Acts upstream of or within T cell differentiation and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system; colon; genitourinary system; sensory organ; and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and primary immunodeficiency disease. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 5.7), frontal lobe adult (RPKM 2.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 60.95 cM; 11 D

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96988833..97006157, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97098007..97115331, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T-bet deficiency and Hic1 induction override TGF-beta-dependency in the formation of CD103[+] intestine-resident memory CD8[+] T cells.
Title: T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103(+) intestine-resident memory CD8(+) T cells.
Effect of ADSCs on Th17/Treg and T-bet/GATA-3 in model mice with primary immune thrombocytopenia.
Title: Effect of ADSCs on Th17/Treg and T-bet/GATA-3 in model mice with primary immune thrombocytopenia.
Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4[+] T cells with brain-homing capacity.
Title: Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4(+) T cells with brain-homing capacity.
The transcription factor T-bet promotes the pathogenesis of nonalcoholic fatty liver disease by upregulating intrahepatic inflammation.
Title: The transcription factor T-bet promotes the pathogenesis of nonalcoholic fatty liver disease by upregulating intrahepatic inflammation.
T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn[-/-] mice.
Title: T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn(-/-) mice.
Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18.
Title: Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18.
Transfer of mesenchymal stem cell mitochondria to CD4[+] T cells contributes to repress Th1 differentiation by downregulating T-bet expression.
Title: Transfer of mesenchymal stem cell mitochondria to CD4(+) T cells contributes to repress Th1 differentiation by downregulating T-bet expression.
Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-alpha during Acute and Chronic Lung Allograft Rejection.
Title: Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection.
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.
Title: Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.
The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes.
Title: The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes.

Submit: New GeneRIF Correction See all GeneRIFs (238)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (8) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC64996P1 (e-PCR)
- UniSTS:273429

PMC122806P1 (e-PCR)
- UniSTS:270410

PMC122806P2 (e-PCR)
- UniSTS:270411

Tbx21 (e-PCR), detects polymorphism
- UniSTS:463956

PMC213492P1 (e-PCR)
- UniSTS:272041

PMC136952P1 (e-PCR)
- UniSTS:270808

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 1 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T-helper 17 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T-helper 17 cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T-helper 2 cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T-helper 2 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: T-box transcription factor TBX21

Names: T-box protein 21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019507.2 → NP_062380.2 T-box transcription factor TBX21

Status: VALIDATED

Source sequence(s)

AK054495, AL627445, BC137986

Consensus CDS

CCDS25315.1

UniProtKB/Swiss-Prot

Q3U150, Q9JKD8, Q9R0A6

Related

ENSMUSP00000001484.3, ENSMUST00000001484.3

Conserved Domains (2) summary

pfam00907
Location:138 → 325

T-box; T-box

pfam16176
Location:393 → 520

T-box_assoc; T-box transcription factor-associated