MIER1 MIER1 transcriptional regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIER1provided by HGNC
Official Full Name: MIER1 transcriptional regulatorprovided by HGNC
Primary source: HGNC:HGNC:29657
See related: Ensembl:ENSG00000198160 MIM:616848; AllianceGenome:HGNC:29657
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ER1; MI-ER1
Summary: This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
Expression: Ubiquitous expression in bone marrow (RPKM 19.6), colon (RPKM 10.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p31.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (66924990..66988619)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (66802518..66866111)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (67390673..67454302)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A potential histone-chaperone activity for the MIER1 histone deacetylase complex.
Title: A potential histone-chaperone activity for the MIER1 histone deacetylase complex.
Histone deacetylase assays confirmed that MIER2, but not MIER3 complexes, have associated deacetylase activity.
Title: Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases
Title: Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
Insulin and IGF-1 alter the subcellular localization of MIER1alpha in breast carcinoma cells.
Title: Insulin and IGF-1, but not 17β-estradiol, alter the subcellular localization of MIER1α in MCF7 breast carcinoma cells.
nuclear targeting of MIER1alpha requires an intact ELM2 domain and is dependent on interaction with HDAC1/2
Title: Nuclear localization of the transcriptional regulator MIER1α requires interaction with HDAC1/2 in breast cancer cells.
the first immunohistochemical study of the MIER1alpha protein expression pattern in human tissues, is reported.
Title: Protein expression pattern of human MIER1 alpha, a novel estrogen receptor binding protein.
Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells
Title: Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells.
Loss of nuclear MI-ER1 alpha might contribute to the development of invasive breast carcinoma
Title: Changes in subcellular localisation of MI-ER1 alpha, a novel oestrogen receptor-alpha interacting protein, is associated with breast cancer progression.
we investigated the role of hMI-ER1alpha and hMI-ER1beta in the regulation of transcription.We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).
Title: Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.
the association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters
Title: The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74969 (e-PCR)
- UniSTS:25862

SHGC-53361 (e-PCR)
- UniSTS:13929

SHGC-74961 (e-PCR)
- UniSTS:32662

D1S1897E (e-PCR)
- UniSTS:58790

SHGC-74968 (e-PCR)
- UniSTS:56242

SHGC-156091 (e-PCR)
- UniSTS:185269

RH70050 (e-PCR)
- UniSTS:90615

Clone Names

KIAA1610, MGC131940, MGC150640, MGC150641, DKFZp781G0451

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	HMP more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mesoderm induction early response protein 1

Names: mesoderm induction early response 1 homolog; mesoderm induction early response 1, transcriptional regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029847.1 RefSeqGene

Range

5096..68725

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001077700.3 → NP_001071168.2 mesoderm induction early response protein 1 isoform b

See identical proteins and their annotated locations for NP_001071168.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses an alternate upstream translation start site, compared to variant 1. The resulting isoform (b) has a longer and distinct N-terminus, compared to isoform a.

Source sequence(s)

AK302061, AL500525, BM987758

Consensus CDS

CCDS53326.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000383820.1, ENST00000401041.6

Conserved Domains (2) summary

cd11661
Location:341 → 385

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:235 → 284

ELM2; ELM2 domain
NM_001077701.3 → NP_001071169.1 mesoderm induction early response protein 1 isoform c

See identical proteins and their annotated locations for NP_001071169.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (c, also known as N3-beta) has a shorter and distinct N-terminus, compared to isoform a.

Source sequence(s)

AF515446, AL500525, BM987758

Consensus CDS

CCDS41348.1

UniProtKB/Swiss-Prot

C9JFD4, Q08AE0, Q32NC4, Q5T104, Q5TAD1, Q5TAD2, Q5TAD4, Q5TAD5, Q6AHY8, Q86TB4, Q8N108, Q8N156, Q8N161, Q8NC37, Q8NES4, Q8NES5, Q8NES6, Q8WWG2, Q9HCG2

Related

ENSP00000347514.3, ENST00000355356.3

Conserved Domains (2) summary

cd11661
Location:288 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:182 → 231

ELM2; ELM2 domain
NM_001077702.3 → NP_001071170.2 mesoderm induction early response protein 1 isoform d

See identical proteins and their annotated locations for NP_001071170.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AF515448, AK302061, AL500525, BM987758

Consensus CDS

CCDS53327.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000360055.1, ENST00000371016.5

Conserved Domains (2) summary

cd11661
Location:305 → 349

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:199 → 248

ELM2; ELM2 domain
NM_001077703.3 → NP_001071171.2 mesoderm induction early response protein 1 isoform e

See identical proteins and their annotated locations for NP_001071171.2

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region, uses an alternate upstream translation start site, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (e) has a longer and distinct N-terminus and a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AK302061, AL500525, AY124187, BM987758

Consensus CDS

CCDS53325.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000360053.1, ENST00000371014.5

Conserved Domains (2) summary

cd11661
Location:341 → 385

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:235 → 284

ELM2; ELM2 domain
NM_001077704.3 → NP_001071172.1 mesoderm induction early response protein 1 isoform f

See identical proteins and their annotated locations for NP_001071172.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (f, also known as N3-alpha), has shorter and distinct N- and C-termini, compared to isoform a.

Source sequence(s)

AL500525, AY124188, BM987758

Consensus CDS

CCDS41347.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000383821.3, ENST00000401042.7

Conserved Domains (2) summary

cd11661
Location:288 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:182 → 231

ELM2; ELM2 domain
NM_001146110.2 → NP_001139582.1 mesoderm induction early response protein 1 isoform a

See identical proteins and their annotated locations for NP_001139582.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 10 encode the same isoform (a).

Source sequence(s)

AK302061, AK307717, AL500525, BC108726, BM987758

Consensus CDS

CCDS53329.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000350321.2, ENST00000357692.6

Conserved Domains (2) summary

cd11661
Location:305 → 349

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:199 → 248

ELM2; ELM2 domain
NM_001146111.2 → NP_001139583.1 mesoderm induction early response protein 1 isoform g

See identical proteins and their annotated locations for NP_001139583.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (g) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AK302061, AL500525, BC108726, BM987758

Consensus CDS

CCDS53328.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000360057.3, ENST00000371018.7

Conserved Domains (2) summary

cd11661
Location:305 → 349

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:199 → 248

ELM2; ELM2 domain
NM_001146112.2 → NP_001139584.1 mesoderm induction early response protein 1 isoform h

See identical proteins and their annotated locations for NP_001139584.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (h) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AF515446, AK302061, AL139216, AL500525, BM987758

UniProtKB/Swiss-Prot

Q8N108

Conserved Domains (2) summary

cd11661
Location:261 → 305

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:155 → 204

ELM2; ELM2 domain
NM_001146113.2 → NP_001139585.1 mesoderm induction early response protein 1 isoform i

See identical proteins and their annotated locations for NP_001139585.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks two alternate exons in the 5' coding region, initiates translation at a downsteram in-frame start codon, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (i) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AK302061, AL500525, BC125217, BM987758

Consensus CDS

CCDS53330.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000348253.6, ENST00000355977.10

Conserved Domains (2) summary

cd11661
Location:225 → 269

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:119 → 168

ELM2; ELM2 domain
NM_001278215.2 → NP_001265144.1 mesoderm induction early response protein 1 isoform j

See identical proteins and their annotated locations for NP_001265144.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks multiple 3' exons and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (j) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AL139216, BC066898

Consensus CDS

CCDS60163.1

UniProtKB/Swiss-Prot

Q8N108

Related

ENSP00000360051.2, ENST00000371012.6
NM_001350530.2 → NP_001337459.1 mesoderm induction early response protein 1 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (12) contains an alternate exon in its 5' coding region, resulting in a shorter 5' UTR and the use of an alternate upstream translation start site, compared to variant 1. The resulting isoform (k) has a longer and distinct N-terminus, compared to isoform a

Source sequence(s)

AF515448, AK302061, AL139216, AL500525, BM987758, CB998535

Conserved Domains (2) summary

cd11661
Location:378 → 422

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:272 → 321

ELM2; ELM2 domain
NM_020948.4 → NP_065999.2 mesoderm induction early response protein 1 isoform a

See identical proteins and their annotated locations for NP_065999.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 10 encode the same isoform (a).

Source sequence(s)

AF515448, AK302061, AL500525, BM987758

Consensus CDS

CCDS53329.1

UniProtKB/Swiss-Prot

Q8N108

Conserved Domains (2) summary

cd11661
Location:305 → 349

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:199 → 248

ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

66924990..66988619

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017001923.2 → XP_016857412.1 mesoderm induction early response protein 1 isoform X4
XM_011541865.3 → XP_011540167.1 mesoderm induction early response protein 1 isoform X1

Conserved Domains (3) summary

smart00717
Location:365 → 410

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:365 → 409

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:259 → 308

ELM2; ELM2 domain
XM_047426266.1 → XP_047282222.1 mesoderm induction early response protein 1 isoform X10
XM_017001928.3 → XP_016857417.1 mesoderm induction early response protein 1 isoform X6

UniProtKB/Swiss-Prot

Q8N108

Conserved Domains (2) summary

cd11661
Location:287 → 331

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:181 → 230

ELM2; ELM2 domain
XM_047426256.1 → XP_047282212.1 mesoderm induction early response protein 1 isoform X3
XM_047426263.1 → XP_047282219.1 mesoderm induction early response protein 1 isoform X5
XM_047426255.1 → XP_047282211.1 mesoderm induction early response protein 1 isoform X3
XM_017001924.2 → XP_016857413.1 mesoderm induction early response protein 1 isoform X5

UniProtKB/Swiss-Prot

Q8N108

Conserved Domains (2) summary

cd11661
Location:305 → 349

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:199 → 248

ELM2; ELM2 domain
XM_017001919.2 → XP_016857408.1 mesoderm induction early response protein 1 isoform X2

Conserved Domains (3) summary

smart00717
Location:324 → 369

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:324 → 368

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:218 → 267

ELM2; ELM2 domain
XM_047426260.1 → XP_047282216.1 mesoderm induction early response protein 1 isoform X5
XM_017001931.2 → XP_016857420.1 mesoderm induction early response protein 1 isoform X8

UniProtKB/Swiss-Prot

Q8N108

Conserved Domains (2) summary

cd11661
Location:261 → 305

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:155 → 204

ELM2; ELM2 domain
XM_047426264.1 → XP_047282220.1 mesoderm induction early response protein 1 isoform X7
XM_017001927.2 → XP_016857416.1 mesoderm induction early response protein 1 isoform X6

UniProtKB/Swiss-Prot

Q8N108

Conserved Domains (2) summary

cd11661
Location:287 → 331

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:181 → 230

ELM2; ELM2 domain
XM_047426265.1 → XP_047282221.1 mesoderm induction early response protein 1 isoform X9
XM_017001920.2 → XP_016857409.1 mesoderm induction early response protein 1 isoform X2

Conserved Domains (3) summary

smart00717
Location:324 → 369

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:324 → 368

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:218 → 267

ELM2; ELM2 domain
XM_017001930.2 → XP_016857419.1 mesoderm induction early response protein 1 isoform X7

Conserved Domains (2) summary

cd11661
Location:287 → 331

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:181 → 230

ELM2; ELM2 domain
XM_017001933.2 → XP_016857422.1 mesoderm induction early response protein 1 isoform X9
XM_017001934.2 → XP_016857423.1 mesoderm induction early response protein 1 isoform X9

RNA

XR_007062438.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

66802518..66866111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054337911.1 → XP_054193886.1 mesoderm induction early response protein 1 isoform X4
XM_054337908.1 → XP_054193883.1 mesoderm induction early response protein 1 isoform X1
XM_054337921.1 → XP_054193896.1 mesoderm induction early response protein 1 isoform X10
XM_054337914.1 → XP_054193889.1 mesoderm induction early response protein 1 isoform X6
XM_054337912.1 → XP_054193887.1 mesoderm induction early response protein 1 isoform X5
XM_054337913.1 → XP_054193888.1 mesoderm induction early response protein 1 isoform X5
XM_054337910.1 → XP_054193885.1 mesoderm induction early response protein 1 isoform X3
XM_054337909.1 → XP_054193884.1 mesoderm induction early response protein 1 isoform X2
XM_054337917.1 → XP_054193892.1 mesoderm induction early response protein 1 isoform X8
XM_054337920.1 → XP_054193895.1 mesoderm induction early response protein 1 isoform X2
XM_054337916.1 → XP_054193891.1 mesoderm induction early response protein 1 isoform X6
XM_054337915.1 → XP_054193890.1 mesoderm induction early response protein 1 isoform X7
XM_054337918.1 → XP_054193893.1 mesoderm induction early response protein 1 isoform X9
XM_054337919.1 → XP_054193894.1 mesoderm induction early response protein 1 isoform X9