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TIMP2 TIMP metallopeptidase inhibitor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574357, updated on 17-Aug-2024

Summary

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Official Symbol
TIMP2provided by VGNC
Official Full Name
TIMP metallopeptidase inhibitor 2provided by VGNC
Primary source
VGNC:VGNC:99300
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
TIMP-2
Orthologs
human mouse all
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Genomic context

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See TIMP2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
8
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (75177672..75249178, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (72670541..72691124, complement)

Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene cytohesin 1 Neighboring gene ubiquitin specific peptidase 36 Neighboring gene CEP295 N-terminal like Neighboring gene galectin 3 binding protein Neighboring gene calcium activated nucleotidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
metalloproteinase inhibitor 2
Names
tissue inhibitor of matrix metalloproteinase-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041769.1 Reference Mmul_10 Primary Assembly

    Range
    75177672..75249178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028836870.1 → XP_028692703.1  metalloproteinase inhibitor 2 isoform X1

    UniProtKB/TrEMBL
    H9FBZ7, H9YV73
    Conserved Domains (1) summary
    cd03585
    Location:27 → 209
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  2. XM_028836873.1 → XP_028692706.1  metalloproteinase inhibitor 2 isoform X4

    UniProtKB/TrEMBL
    G7NH08
    Conserved Domains (1) summary
    cl02512
    Location:1 → 132
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

  3. XM_028836872.1 → XP_028692705.1  metalloproteinase inhibitor 2 isoform X3

    UniProtKB/TrEMBL
    G7NH08
    Conserved Domains (1) summary
    cd03585
    Location:2 → 166
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  4. XM_028836871.1 → XP_028692704.1  metalloproteinase inhibitor 2 isoform X2

    UniProtKB/TrEMBL
    G7NH08
    Conserved Domains (1) summary
    cd03585
    Location:12 → 176
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
Nucleotide Protein
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