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TLR2 toll like receptor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574290, updated on 17-Aug-2024

Summary

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Official Symbol
TLR2provided by VGNC
Official Full Name
toll like receptor 2provided by VGNC
Primary source
VGNC:VGNC:100281
See related
Ensembl:ENSMMUG00000015847
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See TLR2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (151322435..151347090)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (153599598..153621293)

Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain phosphoinositide-interacting protein 4 pseudogene Neighboring gene toll-like receptor 2 Neighboring gene ring finger protein 175 Neighboring gene secreted frizzled related protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques. Takaki A, et al. Immunogenetics, 2012 Jan. PMID 21744114
  2. Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis. Bernardino AL, et al. Infect Immun, 2008 Oct. PMID 18694963, Free PMC Article
  3. Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions. Mothapo KM, et al. J Neurovirol, 2017 Apr. PMID 27882497
  4. Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Sanghavi SK, et al. Immunogenetics, 2004 Dec. PMID 15578265
  5. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cerebrospinal fluid soluble TLR2 and TLR4 may play a role in HIV/SIV-related neuroinflammation and subsequent neuropathology.
    Title: Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.
  2. TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
    Title: Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques.
  3. The results indicate that microglia and astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.
    Title: Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables triacyl lipopeptide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
toll-like receptor 2
NP_001123897.1
XP_014994837.2
XP_014994838.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130425.1 → NP_001123897.1  toll-like receptor 2 precursor

    See identical proteins and their annotated locations for NP_001123897.1

    Status: PROVISIONAL

    Source sequence(s)
    AB445630
    UniProtKB/Swiss-Prot
    B3Y618
    UniProtKB/TrEMBL
    B6CJY9, F7CD54
    Conserved Domains (8) summary
    PRK15370
    Location:326 → 558
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:533 → 586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640 → 784
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:57 → 77
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:27 → 48
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:57 → 370
    internalin_A; class 1 internalin InlA
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat
    NF033190
    Location:47 → 205
    inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041758.1 Reference Mmul_10 Primary Assembly

    Range
    151322435..151347090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015139351.2 → XP_014994837.2  toll-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A5K1U6N5, B6CJY9, F7CD54
    Related
    ENSMMUP00000020834.4, ENSMMUT00000022268.4
    Conserved Domains (7) summary
    PRK15370
    Location:326 → 558
    PRK15370; E3 ubiquitin-protein ligase SlrP; Provisional
    smart00082
    Location:533 → 586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640 → 784
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:54 → 206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:57 → 77
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:27 → 48
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  2. XM_015139352.2 → XP_014994838.2  toll-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A5K1U6N5, B6CJY9, F7CD54
    Conserved Domains (7) summary
    PRK15370
    Location:326 → 558
    PRK15370; E3 ubiquitin-protein ligase SlrP; Provisional
    smart00082
    Location:533 → 586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640 → 784
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:54 → 206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:57 → 77
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:27 → 48
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3Y618.1 GenPept UniProtKB/Swiss-Prot:B3Y618

Gene LinkOut

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