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OPTN optineurin [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574252, updated on 17-Aug-2024

Summary

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Official Symbol
OPTNprovided by VGNC
Official Full Name
optineurinprovided by VGNC
Primary source
VGNC:VGNC:75415
See related
Ensembl:ENSMMUG00000005601
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See OPTN in Genome Data Viewer
Location:
chromosome: 9
Exon count:
20
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (14253526..14305816)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (13181621..13228891)

Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107000046 Neighboring gene coiled-coil domain containing 3 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene minichromosome maintenance 10 replication initiation factor Neighboring gene upper zone of growth plate and cartilage matrix associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression profiling of optineurin in the rhesus monkey. Rezaie T, et al. Invest Ophthalmol Vis Sci, 2005 Jul. PMID 15980228
  2. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Rezaie T, et al. Science, 2002 Feb 8. PMID 11834836
  3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi ribbon formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
optineurin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032897.1 → NP_001028069.1  optineurin

    See identical proteins and their annotated locations for NP_001028069.1

    Status: PROVISIONAL

    Source sequence(s)
    AY228374
    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Related
    ENSMMUP00000007407.4, ENSMMUT00000007881.4
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041762.1 Reference Mmul_10 Primary Assembly

    Range
    14253526..14305816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028853221.1 → XP_028709054.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Related
    ENSMMUP00000067667.1, ENSMMUT00000102245.1
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  2. XM_028853223.1 → XP_028709056.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  3. XM_028853222.1 → XP_028709055.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Related
    ENSMMUP00000036259.3, ENSMMUT00000043250.3
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  4. XM_028853220.1 → XP_028709053.1  optineurin isoform X2

    UniProtKB/TrEMBL
    A0A5F7ZL36, G7N1L3
    Related
    ENSMMUP00000065325.1, ENSMMUT00000100614.1
    Conserved Domains (4) summary
    COG1196
    Location:100 → 438
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:59 → 125
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:567 → 592
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:424 → 523
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  5. XM_028853224.1 → XP_028709057.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  6. XM_015146463.2 → XP_015001949.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Related
    ENSMMUP00000079351.1, ENSMMUT00000092013.1
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  7. XM_015146465.2 → XP_015001951.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  8. XM_028853219.1 → XP_028709052.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Related
    ENSMMUP00000071942.1, ENSMMUT00000109882.1
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

  9. XM_015146462.2 → XP_015001948.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q861Q8
    UniProtKB/TrEMBL
    G7N1L3, H9FNG7
    Conserved Domains (4) summary
    COG1196
    Location:199 → 477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11577
    Location:37 → 103
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:545 → 570
    zf_C2H2_10; C2H2 type zinc-finger
    pfam16516
    Location:402 → 501
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q861Q8.1 GenPept UniProtKB/Swiss-Prot:Q861Q8

Gene LinkOut

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