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NR1I2 nuclear receptor subfamily 1 group I member 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574226, updated on 17-Aug-2024

Summary

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Official Symbol
NR1I2provided by VGNC
Official Full Name
nuclear receptor subfamily 1 group I member 2provided by VGNC
Primary source
VGNC:VGNC:75507
See related
Ensembl:ENSMMUG00000001976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
PXR
Orthologs
human mouse all
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Genomic context

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See NR1I2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (156457379..156467606, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (40967813..40978063)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-6529 Neighboring gene glycogen synthase kinase 3 beta Neighboring gene presenilins-associated rhomboid-like protein, mitochondrial pseudogene Neighboring gene prohibitin pseudogene Neighboring gene cilia and flagella associated protein 91

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Moore LB, et al. Mol Endocrinol, 2002 May. PMID 11981033
  2. Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. Magness CL, et al. Genome Biol, 2005. PMID 15998449, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor subfamily 1 group I member 2
Names
orphan nuclear receptor PXR
pregnane X receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032882.3 → NP_001028054.3  nuclear receptor subfamily 1 group I member 2

    See identical proteins and their annotated locations for NP_001028054.3

    Status: VALIDATED

    Source sequence(s)
    AF454671
    UniProtKB/Swiss-Prot
    Q8SQ01
    UniProtKB/TrEMBL
    A0A5S6RAZ2, A0A8J8XCK4, F6VGK2, G7MKE8
    Related
    ENSMMUP00000002638.2, ENSMMUT00000002794.3
    Conserved Domains (2) summary
    cd06934
    Location:143 → 428
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:40 → 127
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    156457379..156467606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SQ01.1 GenPept UniProtKB/Swiss-Prot:Q8SQ01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials