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CD209 CD209 molecule [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574211, updated on 6-Oct-2023

Summary

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Gene symbol
CD209
Gene description
CD209 molecule
See related
Ensembl:ENSMMUG00000022463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
DC-SIGN
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Genomic context

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See CD209 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
7
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (7686682..7691096, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (7948861..7953275, complement)

Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene C-type lectin CD209L2 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 pseudogene Neighboring gene C-type lectin domain family 4 member G-like Neighboring gene uncharacterized LOC114674058

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection. Yearley JH, et al. Dev Comp Immunol, 2008. PMID 18606180
  2. Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the rhesus macaque: DC-SIGN is a putative marker of the recognition of pregnancy. Breburda EE, et al. Placenta, 2006 Jan. PMID 16310033
  3. Gene for chinese rhesus macaque DC-SIGN predicts the existence of A but not B isoforms of the protein. Santos PR, et al. AIDS Res Hum Retroviruses, 2002 Sep 1. PMID 12230940
  4. Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Wu L, et al. Proc Natl Acad Sci U S A, 2002 Feb 5. PMID 11818554, Free PMC Article
  5. Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN. Geijtenbeek TB, et al. Immunol Lett, 2001 Nov 1. PMID 11595296

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DC-SIGN expression in mesenteric lymph nodes is significantly downregulated in simian immunodeficiency virus-infected pig-tailed macaques.
    Title: Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection.
  2. DC-SIGN+ cells showed a clear differential distribution in the decidua in the first 2 weeks of pregnancy, being found only adjacent to the implantation site
    Title: Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the rhesus macaque: DC-SIGN is a putative marker of the recognition of pregnancy.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
CD209 antigen
Names
DC-SIGN1
dendritic cell-specific ICAM-3 grabbing non-integrin
dendritic cell-specific ICAM-3-grabbing non-integrin 1
putative mannose-binding C-type lectin mDC-SIGN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032870.1 → NP_001028042.1  CD209 antigen isoform 1

    See identical proteins and their annotated locations for NP_001028042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF391086
    UniProtKB/Swiss-Prot
    Q8HXL6, Q8HXL7, Q8HXL8, Q8HXL9, Q8SQB2, Q95J96, Q95LA8
    Related
    ENSMMUP00000029557.4, ENSMMUT00000031593.4
    Conserved Domains (1) summary
    cd03590
    Location:256 → 379
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

  2. NM_001033089.1 → NP_001028261.1  CD209 antigen isoform 2

    See identical proteins and their annotated locations for NP_001028261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AF369755
    UniProtKB/TrEMBL
    A5X2X8, A5X2Y5
    Conserved Domains (2) summary
    cd03590
    Location:233 → 356
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl03855
    Location:42 → 149
    CemA; CemA family

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041772.1 Reference Mmul_10 Primary Assembly

    Range
    7686682..7691096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95J96.2 GenPept UniProtKB/Swiss-Prot:Q95J96

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