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PTPRZ1 protein tyrosine phosphatase receptor type Z1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574174, updated on 17-Aug-2024

Summary

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Official Symbol
PTPRZ1provided by VGNC
Official Full Name
protein tyrosine phosphatase receptor type Z1provided by VGNC
Primary source
VGNC:VGNC:76625
See related
Ensembl:ENSMMUG00000012418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PTPRZ1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
30
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (148281089..148473558)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (147844844..148040629)

Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule C Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene tetratricopeptide repeat protein 14-like Neighboring gene aminoadipate-semialdehyde synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase zeta
Names
receptor-protein tyrosine phosphatase beta
NP_001265311.1
NP_001265330.1
XP_014990266.2
XP_014990267.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278382.1 → NP_001265311.1  receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JU335709, JV477015, JV515406, JV553208, JV553209
    UniProtKB/TrEMBL
    F7DJJ9
    Related
    ENSMMUP00000016302.4, ENSMMUT00000017408.4
    Conserved Domains (5) summary
    smart00194
    Location:1720 → 1995
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1756 → 1995
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 401
    fn3; Fibronectin type III domain
    pfam07777
    Location:684 → 763
    MFMR; G-box binding protein MFMR

  2. NM_001278401.1 → NP_001265330.1  receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame alternate exon in the 3' coding region compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    JU335709, JV477015, JV515406, JV553208, JV553209
    UniProtKB/TrEMBL
    A0A5F8AB20
    Related
    ENSMMUP00000075133.1, ENSMMUT00000108821.1
    Conserved Domains (5) summary
    smart00194
    Location:1720 → 1988
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1749 → 1988
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 401
    fn3; Fibronectin type III domain
    pfam07777
    Location:684 → 763
    MFMR; G-box binding protein MFMR

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041756.1 Reference Mmul_10 Primary Assembly

    Range
    148281089..148473558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015134780.2 → XP_014990266.2  receptor-type tyrosine-protein phosphatase zeta isoform X1

    Conserved Domains (4) summary
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 395
    fn3; Fibronectin type III domain
    cd17669
    Location:1217 → 1420
    R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
    cl28904
    Location:857 → 1134
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_015134781.2 → XP_014990267.2  receptor-type tyrosine-protein phosphatase zeta isoform X2

    Conserved Domains (4) summary
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 395
    fn3; Fibronectin type III domain
    cd17669
    Location:1210 → 1413
    R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
    cl28904
    Location:857 → 1127
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein
Heading Accession and Version

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