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l(2)41Ab lethal (2) 41Ab [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740691, updated on 9-Dec-2024

Summary

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Official Symbol
l(2)41Abprovided by FlyBase
Official Full Name
lethal (2) 41Abprovided by FlyBase
Primary source
FLYBASE:FBgn0262123
Locus tag
Dmel_CG41265
See related
AllianceGenome:FB:FBgn0262123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1(2R)B; 41Ab; CG40214; CG40334; CG41265; Dmel\CG41265; GroupI; l(2)EMS45-10; l(2R)B
Summary
Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to be active in cytoplasm. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 15. Orthologous to human CCDC40 (coiled-coil domain 40 molecular ruler complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See l(2)41Ab in Genome Data Viewer
Location:
41A1-41A1; 2-55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1349392..1443935)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (476025..570568)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44042 Neighboring gene long non-coding RNA:CR44043 Neighboring gene yeti Neighboring gene Maf1 Neighboring gene Branched chain keto acid dehydrogenase E1 subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster. Eberl DF, et al. Genetics, 1993 May. PMID 8514136, Free PMC Article
  2. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article
  3. Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups. Hilliker AJ. Genetics, 1976 Aug. PMID 823073, Free PMC Article
  4. 1(2)41Aa, a heterochromatic gene of Drosophila melanogaster, is required for mitotic and meiotic chromosome condensation. Cenci G, et al. Genet Res, 2003 Feb. PMID 12693679
  5. Cytogenetic analysis of the second chromosome heterochromatin of Drosophila melanogaster. Dimitri P. Genetics, 1991 Mar. PMID 1707844, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

mobile_element

  • Loc: 1374261-1374683 mobile_element_type = transposon:invader1{}6536
  • Loc: 1396478-1397528 mobile_element_type = transposon:1360{}6326
  • Loc: 1423542-1424649 mobile_element_type = transposon:1360{}6328

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in axoneme assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lethal (2) 41Ab
Names
CG41265-PA
CG41265-PB
l(2)41Ab-PA
l(2)41Ab-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    1349392..1443935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001110887.2 → NP_001104357.1  lethal (2) 41Ab, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B7P7M6
    Conserved Domains (1) summary
    COG1196
    Location:53 → 808
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001110886.2 → NP_001104356.1  lethal (2) 41Ab, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHM9
    Conserved Domains (1) summary
    COG1196
    Location:1 → 725
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B7P7M6 A0A0B7P7M6
A0A0C4DHM9 A0A0C4DHM9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials