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pgc polar granule component [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740599, updated on 9-Dec-2024

Summary

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Official Symbol
pgcprovided by FlyBase
Official Full Name
polar granule componentprovided by FlyBase
Primary source
FLYBASE:FBgn0016053
Locus tag
Dmel_CG32885
See related
AllianceGenome:FB:FBgn0016053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11296; CG32885; CR32885; Dmel\CG32885; Pgc; pgc-1; Pgc1; PGC1; pgr
Summary
Involved in several processes, including germ-line cyst formation; pole cell development; and regulation of gene expression. Located in P granule. Is expressed in germline cell; organism; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See pgc in Genome Data Viewer
Location:
58D3-58D3; 2-99 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22330200..22332813)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18217705..18220318)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44756 Neighboring gene Gp150 Neighboring gene uncharacterized protein Neighboring gene Liprin-gamma Neighboring gene Type III alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Computational modeling offers new insight into Drosophila germ granule development. Valentino M, et al. Biophys J, 2022 Apr 19. PMID 35288123, Free PMC Article
  2. Distinct cis-acting elements mediate targeting and clustering of Drosophila polar granule mRNAs. Eagle WVI, et al. Development, 2018 Nov 22. PMID 30333216, Free PMC Article
  3. Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and Bombyx. Dhulkotia D, et al. Dev Genes Evol, 2000 Mar. PMID 11180815
  4. Repression of RNA polymerase II transcription by a Drosophila oligopeptide. Timinszky G, et al. PLoS One, 2008 Jun 25. PMID 18575576, Free PMC Article
  5. Maintaining sufficient nanos is a critical function for polar granule component in the specification of primordial germ cells. Deshpande G, et al. G3 (Bethesda), 2012 Nov. PMID 23173091, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Individual nos and pgc transcripts can populate the same nascent germ granule, and these first transcripts then act as seeds, recruiting additional like transcripts to form homotypic clusters.
    Title: Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules.
  2. pgc embryos have greatly reduced levels of Nos protein.
    Title: Maintaining sufficient nanos is a critical function for polar granule component in the specification of primordial germ cells.
  3. lack of pgc partly ameliorates the cellularization defect of tor mutants, thus revealing a functional antagonism between pgc and tor in the specification of germline and somatic properties.
    Title: A functional antagonism between the pgc germline repressor and torso in the development of somatic cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line cyst formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pole plasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polar granule component
Names
58D gene
CG32885-PA
CG32885-PC
CG32885-PD
pgc-PA
pgc-PC
pgc-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22330200..22332813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103942.2 → NP_001097412.1  polar granule component, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYL7

  2. NM_001103941.2 → NP_001097411.1  polar granule component, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYL7

  3. NM_001299786.1 → NP_001286715.1  polar granule component, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286715.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYL7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYL7 A8DYL7
Q8SZ69 Q8SZ69

Gene LinkOut

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