U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ND-MWFE NADH dehydrogenase (ubiquinone) MWFE subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740593, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ND-MWFEprovided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) MWFE subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0085468
Locus tag
Dmel_CG34439
See related
AllianceGenome:FB:FBgn0085468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH49308; CG13328; CG17054; CG30057; CG34439; Dmel\CG34439; dNDUFA1; l(2)c00093; NDUFA1
Summary
Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 12. Orthologous to human NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ND-MWFE in Genome Data Viewer
Location:
49F4-49F4; 2-68 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13158666..13160190)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9046171..9047695)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chromosome associated protein G Neighboring gene Activated Cdc42 kinase-like Neighboring gene Tripeptidyl-peptidase II Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein Neighboring gene Glial Lazarillo

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster. Holland C, et al. Genetics, 2011 Jun. PMID 21441212, Free PMC Article
  2. Conservation of an RNA regulatory map between Drosophila and mammals. Brooks AN, et al. Genome Res, 2011 Feb. PMID 20921232, Free PMC Article
  3. SR proteins control a complex network of RNA-processing events. Bradley T, et al. RNA, 2015 Jan. PMID 25414008, Free PMC Article
  4. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
  5. Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Murari A, et al. Cell Rep, 2023 Aug 29. PMID 37516961, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NADH dehydrogenase (ubiquinone) MWFE subunit
Names
CG34439-PA
CG34439-PB
NADH ubiquinone oxidoreductase MWFE
ND-MWFE-PA
ND-MWFE-PB
lethal (2) c00093

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13158666..13160190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103827.2 → NP_001097297.1  NADH dehydrogenase (ubiquinone) MWFE subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097297.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYC4
    Conserved Domains (2) summary
    pfam08496
    Location:93 → 119
    Peptidase_S49_N; Peptidase family S49 N-terminal
    pfam15879
    Location:4 → 55
    MWFE; NADH-ubiquinone oxidoreductase MWFE subunit

  2. NM_001103826.2 → NP_001097296.1  NADH dehydrogenase (ubiquinone) MWFE subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYC5, Q8SXW2
    Conserved Domains (1) summary
    pfam15879
    Location:4 → 55
    MWFE; NADH-ubiquinone oxidoreductase MWFE subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYC4 A8DYC4
A8DYC5 A8DYC5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous