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Fili Fish-lips [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740472, updated on 9-Dec-2024

Summary

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Official Symbol
Filiprovided by FlyBase
Official Full Name
Fish-lipsprovided by FlyBase
Primary source
FLYBASE:FBgn0085397
Locus tag
Dmel_CG34368
See related
AllianceGenome:FB:FBgn0085397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13487; CG34368; CG4054; CT13464; CT32855; Dmel\CG34368; fili
Old locus tag
CG13487; CG4054; Dmel_CG13487; Dmel_CG4045; Dmel_CG4054
Summary
Involved in regulation of apoptotic process. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Fili in Genome Data Viewer
Location:
58A3-58A4; 2-97 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21872030..21946259)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17759535..17833764)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cookie monster Neighboring gene Protein phosphatase N at 58A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-Quality Genome Assemblies Reveal Evolutionary Dynamics of Repetitive DNA and Structural Rearrangements in the Drosophila virilis Subgroup. Flynn JM, et al. Genome Biol Evol, 2024 Jan 5. PMID 38159044, Free PMC Article
  2. Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons. Xie Q, et al. Proc Natl Acad Sci U S A, 2019 Aug 6. PMID 31341080, Free PMC Article
  3. Visualization of binding patterns for five Leucine-rich repeat proteins in the Drosophila embryo. Bali N, et al. MicroPubl Biol, 2019 Dec 18. PMID 32550403, Free PMC Article
  4. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
  5. Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster. Dobson AJ, et al. Nat Commun, 2015 Feb 18. PMID 25692519, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Fish-lips
Names
CG34368-PC
CG34368-PD
CG34368-PE
Fili-PC
Fili-PD
Fili-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21872030..21946259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382077.1 → NP_001369108.1  Fish-lips, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7U5
    Conserved Domains (4) summary
    COG4886
    Location:161 → 354
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:75 → 97
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:98 → 121
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:120 → 180
    LRR_8; Leucine rich repeat

  2. NM_001103932.2 → NP_001097402.1  Fish-lips, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097402.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U1A7
    Conserved Domains (4) summary
    cd00116
    Location:79 → 327
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:75 → 97
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:98 → 121
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:265 → 321
    LRR_8; Leucine rich repeat

  3. NM_137775.2 → NP_611619.2  Fish-lips, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611619.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U1A7
    Conserved Domains (4) summary
    cd00116
    Location:79 → 327
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:75 → 97
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:98 → 121
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:265 → 321
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6M3Q7U5 A0A6M3Q7U5
Q5U1A7 Q5U1A7

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