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SLO2 slowpoke 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740325, updated on 4-Jan-2025

Summary

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Official Symbol
SLO2provided by FlyBase
Official Full Name
slowpoke 2provided by FlyBase
Primary source
FLYBASE:FBgn0261698
Locus tag
Dmel_CG42732
See related
AllianceGenome:FB:FBgn0261698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12897; CG12899; CG12901; CG12904; CG34363; CG42732; Dmel\CG42732; Dm_2R:24301; Dm_2R:24438; dSlo2; dSLO2; Slack; Slo2
Old locus tag
CG12899; CG12904; Dmel_CG12897; Dmel_CG12899; Dmel_CG12904; Dmel_CG34363
Summary
Enables intracellular sodium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See SLO2 in Genome Data Viewer
Location:
47A1-47A7; 2-62 cM
Exon count:
34
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10322195..10416996, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6209700..6304501, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 46a Neighboring gene uncharacterized protein Neighboring gene Nidogen Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 47a Neighboring gene Ionotropic receptor 47b Neighboring gene Ionotropic receptor 47a Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels. Budelli G, et al. J Biol Chem, 2016 Apr 1. PMID 26823461, Free PMC Article
  2. Slo2/K(Na) Channels in Drosophila Protect against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na(+) Current. Byers N, et al. J Neurosci, 2021 Oct 27. PMID 34544836, Free PMC Article
  3. Diurnal protein oscillation profiles in Drosophila head. Du J, et al. FEBS Lett, 2018 Nov. PMID 30311939, Free PMC Article
  4. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. McCormack TJ. Genome Biol, 2003. PMID 12952537, Free PMC Article
  5. Evolution of secretin family GPCR members in the metazoa. Cardoso JC, et al. BMC Evol Biol, 2006 Dec 13. PMID 17166275, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slo2/KNa Channels in Drosophila Protect against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na(+) Current.
    Title: Slo2/K(Na) Channels in Drosophila Protect against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na(+) Current.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium-activated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables intracellular sodium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellular sodium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
slowpoke 2
Names
CG42732-PD
CG42732-PE
CG42732-PF
CG42732-PG
CG42732-PH
CG42732-PI
CG42732-PL
CG42732-PN
CG42732-PO
SLO2-PD
SLO2-PE
SLO2-PF
SLO2-PG
SLO2-PH
SLO2-PI
SLO2-PL
SLO2-PN
SLO2-PO

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10322195..10416996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273934.1 → NP_001260863.1  slowpoke 2, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260863.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF87
    Conserved Domains (2) summary
    pfam03493
    Location:507 → 602
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:302 → 346
    Ion_trans_2; Ion channel

  2. NM_001273933.1 → NP_001260862.1  slowpoke 2, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260862.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFK3
    Conserved Domains (2) summary
    pfam03493
    Location:461 → 556
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:256 → 300
    Ion_trans_2; Ion channel

  3. NM_001259313.2 → NP_001246242.1  slowpoke 2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K738, A0A165TJ88
    Conserved Domains (2) summary
    pfam03493
    Location:457 → 552
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:252 → 296
    Ion_trans_2; Ion channel

  4. NM_001201972.3 → NP_001188901.1  slowpoke 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188901.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHC4
    Conserved Domains (2) summary
    pfam03493
    Location:457 → 552
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:252 → 296
    Ion_trans_2; Ion channel

  5. NM_001273932.1 → NP_001260861.1  slowpoke 2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260861.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEQ3
    Conserved Domains (2) summary
    pfam03493
    Location:457 → 552
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:252 → 296
    Ion_trans_2; Ion channel

  6. NM_001273935.1 → NP_001260864.1  slowpoke 2, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEJ9
    Conserved Domains (2) summary
    pfam03493
    Location:457 → 552
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:252 → 296
    Ion_trans_2; Ion channel

  7. NM_001103788.3 → NP_001097258.2  slowpoke 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097258.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY94
    Conserved Domains (2) summary
    pfam03493
    Location:524 → 619
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:297 → 363
    Ion_trans_2; Ion channel

  8. NM_001103789.3 → NP_001097259.2  slowpoke 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097259.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY93
    Conserved Domains (2) summary
    pfam03493
    Location:524 → 619
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:297 → 363
    Ion_trans_2; Ion channel

  9. NM_001201971.2 → NP_001188900.1  slowpoke 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188900.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD38
    Conserved Domains (2) summary
    pfam03493
    Location:538 → 633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:311 → 377
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD38 A0A0B4JD38
A0A0B4K738 A0A0B4K738
A0A0B4KEJ9 A0A0B4KEJ9
A0A0B4KEQ3 A0A0B4KEQ3
A0A0B4KF87 A0A0B4KF87
A0A0B4KFK3 A0A0B4KFK3
A0A0C4DHC4 A0A0C4DHC4
A8DY93 A8DY93
A8DY94 A8DY94

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