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Stacl Stac-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740318, updated on 4-Jan-2025

Summary

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Official Symbol
Staclprovided by FlyBase
Official Full Name
Stac-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0263980
Locus tag
Dmel_CG43729
See related
AllianceGenome:FB:FBgn0263980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12958; CG12959; CG14163; CG18625; CG30470; CG34318; CG34365; CG43223; CG43729; CG8179; Dmel\CG43729; Dm_2R:47664; Dm_2R:47672; Dstac; mdcds_11908
Old locus tag
CG12958; CG12959; CG18625; CG8179; Dmel_CG12958; Dmel_CG12959; Dmel_CG18625; Dmel_CG30470; Dmel_CG34318; Dmel_CG34365; Dmel_CG43223; Dmel_CG8179
Summary
Enables calcium channel regulator activity. Involved in calcium ion transmembrane transport; locomotion; and positive regulation of cell size. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC (SH3 and cysteine rich domain); STAC2 (SH3 and cysteine rich domain 2); and STAC3 (SH3 and cysteine rich domain 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Stacl in Genome Data Viewer
Location:
51F13-52A4; 2-74 cM
Exon count:
25
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15401096..15471884)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11288601..11359389)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene double parked Neighboring gene SR Protein Kinase Neighboring gene long non-coding RNA:CR45020 Neighboring gene Metchnikowin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dstac is required for normal circadian activity rhythms in Drosophila. Hsu IU, et al. Chronobiol Int, 2018 Jul. PMID 29621409, Free PMC Article
  2. Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles. Hsu IU, et al. Front Physiol, 2020. PMID 33123029, Free PMC Article
  3. Stac protein regulates release of neuropeptides. Hsu IU, et al. Proc Natl Acad Sci U S A, 2020 Nov 24. PMID 33168737, Free PMC Article
  4. A microRNA that controls the emergence of embryonic movement. Menzies JAC, et al. Elife, 2024 Jun 13. PMID 38869942, Free PMC Article
  5. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Cully M, et al. Mol Cell Biol, 2010 Jan. PMID 19917724, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Stac-like
Names
CG43729-PA
CG43729-PC
CG43729-PE
CG43729-PH
CG43729-PI
CG43729-PJ
CG43729-PM
CG43729-PN
CG43729-PO
CG43729-PP
CG43729-PQ
CG43729-PR
CG43729-PS
CG43729-PT
CG43729-PU
CG43729-PV
CG43729-PW
CG43729-PX
Stacl-PA
Stacl-PC
Stacl-PE
Stacl-PH
Stacl-PI
Stacl-PJ
Stacl-PM
Stacl-PN
Stacl-PO
Stacl-PP
Stacl-PQ
Stacl-PR
Stacl-PS
Stacl-PT
Stacl-PU
Stacl-PV
Stacl-PW
Stacl-PX

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15401096..15471884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274065.2 → NP_001260994.1  Stac-like, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260994.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG20
    Conserved Domains (3) summary
    cd00029
    Location:727 → 773
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:1051 → 1102
    SH3; Src Homology 3 domain superfamily

  2. NM_001274066.1 → NP_001260995.1  Stac-like, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFR2
    Conserved Domains (3) summary
    cd00029
    Location:727 → 773
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:1051 → 1102
    SH3; Src Homology 3 domain superfamily

  3. NM_001274067.1 → NP_001260996.1  Stac-like, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260996.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEV7
    Conserved Domains (3) summary
    cd00029
    Location:727 → 773
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:1051 → 1102
    SH3; Src Homology 3 domain superfamily

  4. NM_001299528.1 → NP_001286457.1  Stac-like, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286457.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGK0
    Conserved Domains (3) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:1083 → 1134
    SH3; Src Homology 3 domain superfamily

  5. NM_001274068.2 → NP_001260997.2  Stac-like, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260997.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KER3
    Conserved Domains (3) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:1041 → 1092
    SH3; Src Homology 3 domain superfamily

  6. NM_001299527.1 → NP_001286456.1  Stac-like, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286456.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFI1
    Conserved Domains (3) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:974 → 1025
    SH3; Src Homology 3 domain superfamily

  7. NM_001382114.1 → NP_001369089.1  Stac-like, isoform X [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3QAK8
    Conserved Domains (5) summary
    PHA03247
    Location:20 → 283
    PHA03247; large tegument protein UL36; Provisional
    cd22250
    Location:793 → 848
    ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
    cd20817
    Location:920 → 970
    C1_Stac; protein kinase C conserved region 1 (C1 domain) found in the SH3 and cysteine-rich domain-containing protein (Stac) family
    cl12013
    Location:502 → 701
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:1253 → 1304
    SH3; Src Homology 3 domain superfamily

  8. NM_001299525.1 → NP_001286454.1  Stac-like, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286454.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF79
    Conserved Domains (2) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. NM_001103855.4 → NP_001097325.2  Stac-like, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097325.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYE4
    Conserved Domains (1) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  10. NM_001274069.2 → NP_001260998.2  Stac-like, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260998.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF73
    Conserved Domains (2) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. NM_001299526.1 → NP_001286455.1  Stac-like, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286455.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFG4
    Conserved Domains (2) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl12013
    Location:290 → 489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  12. NM_001299524.1 → NP_001286453.1  Stac-like, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286453.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFF3
    Conserved Domains (1) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  13. NM_001103852.3 → NP_001097322.1  Stac-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097322.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1EC92
    Conserved Domains (1) summary
    cd00029
    Location:708 → 754
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  14. NM_001382113.1 → NP_001369088.1  Stac-like, isoform W [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7M2
    Conserved Domains (3) summary
    PHA03247
    Location:20 → 283
    PHA03247; large tegument protein UL36; Provisional
    cd20817
    Location:920 → 970
    C1_Stac; protein kinase C conserved region 1 (C1 domain) found in the SH3 and cysteine-rich domain-containing protein (Stac) family
    cl12013
    Location:502 → 701
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  15. NM_137192.2 → NP_611036.2  Stac-like, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611036.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHC0, Q29QR2
    Conserved Domains (1) summary
    cd00029
    Location:448 → 494
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  16. NM_001103854.4 → NP_001097324.1  Stac-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097324.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYE7
    Conserved Domains (1) summary
    cd00029
    Location:45 → 91
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  17. NM_001103857.3 → NP_001097327.2  Stac-like, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097327.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYE9
    Conserved Domains (2) summary
    cd00029
    Location:107 → 153
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17036
    Location:431 → 482
    SH3; Src Homology 3 domain superfamily

  18. NM_001103853.4 → NP_001097323.3  Stac-like, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097323.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYE8
    Conserved Domains (1) summary
    pfam00130
    Location:107 → 158
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KER3 A0A0B4KER3
A0A0B4KEV7 A0A0B4KEV7
A0A0B4KF73 A0A0B4KF73
A0A0B4KFR2 A0A0B4KFR2
A0A0B4KG20 A0A0B4KG20
A0A0B4LF79 A0A0B4LF79
A0A0B4LFF3 A0A0B4LFF3
A0A0B4LFG4 A0A0B4LFG4
A0A0B4LFI1 A0A0B4LFI1
A0A0B4LGK0 A0A0B4LGK0
A0A0C4DHC0 A0A0C4DHC0
A0A6M3Q7M2 A0A6M3Q7M2
A0A6M3QAK8 A0A6M3QAK8
A8DYE4 A8DYE4
A8DYE7 A8DYE7
A8DYE8 A8DYE8
A8DYE9 A8DYE9
Q1EC92 Q1EC92

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