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Targ3 Terminal ADP-ribose protein glycohydrolase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740205, updated on 9-Dec-2024

Summary

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Official Symbol
Targ3provided by FlyBase
Official Full Name
Terminal ADP-ribose protein glycohydrolase 3provided by FlyBase
Primary source
FLYBASE:FBgn0085290
Locus tag
Dmel_CG34261
See related
AllianceGenome:FB:FBgn0085290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG34261; Dmel\CG34261; dTarg3
Summary
Predicted to enable ADP-ribosyl-[dinitrogen reductase] hydrolase activity; ADP-ribosylglutamate hydrolase activity; and purine nucleoside binding activity. Predicted to be involved in DNA damage response and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Targ3 in Genome Data Viewer
Location:
78C2-78C2; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21196831..21197738)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21189931..21190838)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene parkin Neighboring gene Terminal ADP-ribose protein glycohydrolase 1 Neighboring gene Terminal ADP-ribose protein glycohydrolase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Fontana P, et al. Nat Commun, 2023 Jun 2. PMID 37268618, Free PMC Article
  2. Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase. Bu S, et al. Cell Rep, 2022 May 31. PMID 35649352
  3. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
  4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-ribosylglutamate hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables purine nucleoside binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleoside metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleoside metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
terminal ADP-ribose protein glycohydrolase 3
Names
CG34261-PB
Targ3-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21196831..21197738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104186.3 → NP_001097656.1  terminal ADP-ribose protein glycohydrolase 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097656.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNW5
    Conserved Domains (1) summary
    cd02901
    Location:7 → 133
    Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNW5 A8JNW5

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