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Drgx Dorsal root ganglia homeobox [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740176, updated on 4-Jan-2025

Summary

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Official Symbol
Drgxprovided by FlyBase
Official Full Name
Dorsal root ganglia homeoboxprovided by FlyBase
Primary source
FLYBASE:FBgn0085369
Locus tag
Dmel_CG34340
See related
AllianceGenome:FB:FBgn0085369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10017; CG2808; CG34340; Dmel\CG34340
Old locus tag
CG10017; CG2808; Dmel_CG10017; Dmel_CG2808
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human DRGX (dorsal root ganglia homeobox). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Drgx in Genome Data Viewer
Location:
24A5-24B1; 2-10 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3662745..3692114)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3662745..3692114)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 36 member A1 Neighboring gene uncharacterized protein Neighboring gene foraging Neighboring gene mir-4972 stem loop Neighboring gene Seminal fluid protein 24Ba Neighboring gene Seminal fluid protein 24Bd Neighboring gene Seminal fluid protein 24Bb Neighboring gene Seminal fluid protein 24Bc Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Controlled expression of Drosophila homeobox loci using the Hostile takeover system. Javeed N, et al. Dev Dyn, 2015 Jun. PMID 25820349, Free PMC Article
  2. Coordinated control of neuronal differentiation and wiring by sustained transcription factors. Özel MN, et al. Science, 2022 Dec 23. PMID 36480601, Free PMC Article
  3. A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in Drosophila. Fernando C, et al. Genetics, 2015 Apr. PMID 25680814, Free PMC Article
  4. Pax3/7 genes reveal conservation and divergence in the arthropod segmentation hierarchy. Davis GK, et al. Dev Biol, 2005 Sep 1. PMID 16083872
  5. Cellular and molecular organization of the Drosophila foregut. Zhu H, et al. Proc Natl Acad Sci U S A, 2024 Mar 12. PMID 38442150, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dorsal root ganglia homeobox
Names
CG34340-PE
CG34340-PF
Drgx-PE
Drgx-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3662745..3692114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298663.1 → NP_001285592.1  dorsal root ganglia homeobox, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285592.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AVV3, A8DYQ2
    Conserved Domains (2) summary
    pfam00046
    Location:56 → 108
    Homeobox; Homeobox domain
    pfam03826
    Location:428 → 445
    OAR; OAR domain

  2. NM_001103605.2 → NP_001097075.2  dorsal root ganglia homeobox, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097075.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AVV3, A8DYQ2
    Conserved Domains (2) summary
    pfam00046
    Location:56 → 108
    Homeobox; Homeobox domain
    pfam03826
    Location:428 → 445
    OAR; OAR domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0AVV3 A0AVV3

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