c6ast4 six-cysteine containing astacin protease 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: c6ast4provided by ZNC
Official Full Name: six-cysteine containing astacin protease 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-050626-100
See related: Ensembl:ENSDARG00000052578 AllianceGenome:ZFIN:ZDB-GENE-050626-100
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:114183
Summary: Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (38635541..38638806, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (38364283..38367548, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: six-cysteine containing astacin protease 4

NP_001020351.1

EC 3.4.24.-

XP_009301601.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025180.1 → NP_001020351.1 six-cysteine containing astacin protease 4 precursor

See identical proteins and their annotated locations for NP_001020351.1

Status: PROVISIONAL

Source sequence(s)

BC097232

UniProtKB/TrEMBL

Q4QRC8

Related

ENSDARP00000115337.1, ENSDART00000144341.4

Conserved Domains (2) summary

pfam01400
Location:78 → 265

Astacin; Astacin (Peptidase family M12A)

cl00064
Location:84 → 265

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

38635541..38638806 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009303326.4 → XP_009301601.1 six-cysteine containing astacin protease 4 isoform X1

UniProtKB/TrEMBL

A0A8M3B483

Conserved Domains (2) summary

pfam01400
Location:76 → 263

Astacin; Astacin (Peptidase family M12A)

cl00064
Location:82 → 263

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...