rragca Ras-related GTP binding Ca [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rragcaprovided by ZNC
Official Full Name: Ras-related GTP binding Caprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-355
See related: Ensembl:ENSDARG00000069829 AllianceGenome:ZFIN:ZDB-GENE-050522-355
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rragc; zgc:111971
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular response to starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm and membrane. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Is expressed in heart. Used to study cardiomyopathy. Orthologous to human RRAGC (Ras related GTP binding C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (33163858..33178129)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (33209828..33224099)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC(S75Y) Cardiomyopathy.
Title: TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagC(S75Y) Cardiomyopathy.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Gtr1-Gtr2 GTPase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ras-related GTP binding Ca

Names: Ras-related GTP binding C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020635.1 → NP_001018471.1 Ras-related GTP binding Ca

See identical proteins and their annotated locations for NP_001018471.1

Status: PROVISIONAL

Source sequence(s)

BC095626

UniProtKB/TrEMBL

Q502N9

Related

ENSDARP00000092718.3, ENSDART00000101943.4

Conserved Domains (2) summary

cd11385
Location:44 → 218

RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

COG1100
Location:44 → 218

Gem1; GTPase SAR1 family domain [General function prediction only]