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dync1li2 dynein, cytoplasmic 1, light intermediate chain 2 [ Danio rerio (zebrafish) ]

Gene ID: 573266, updated on 9-Dec-2024

Summary

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Official Symbol
dync1li2provided by ZNC
Official Full Name
dynein, cytoplasmic 1, light intermediate chain 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-156
See related
Ensembl:ENSDARG00000035924 AllianceGenome:ZFIN:ZDB-GENE-050417-156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc08b04; wu:fc08b04; zgc:112480
Summary
Predicted to enable dynein heavy chain binding activity. Acts upstream of or within regulation of metaphase plate congression; regulation of mitotic cell cycle, embryonic; and regulation of mitotic spindle organization. Predicted to be located in cytoplasm and microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See dync1li2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (44674956..44704877, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (44336221..44365682, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496202 Neighboring gene CKLF-like MARVEL transmembrane domain containing 3 Neighboring gene CKLF-like MARVEL transmembrane domain containing 4 Neighboring gene uncharacterized LOC103911411 Neighboring gene si:dkey-56m19.5 Neighboring gene uncharacterized LOC108190699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Mahale S, et al. Sci Rep, 2016 Dec 23. PMID 28003657, Free PMC Article
  2. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Zhao X, et al. Sci Adv, 2021 Jun. PMID 34117063, Free PMC Article
  3. Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. Drerup CM, et al. Elife, 2017 Apr 17. PMID 28414272, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112480, MGC174291

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytoplasmic dynein 1 light intermediate chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017669.2 → NP_001017669.2  cytoplasmic dynein 1 light intermediate chain 2

    Status: VALIDATED

    Source sequence(s)
    BX511128, CK026114
    UniProtKB/TrEMBL
    A0A8M1N5F3, F1RB89
    Related
    ENSDARP00000031864.7, ENSDART00000037850.8
    Conserved Domains (3) summary
    cd00882
    Location:219 → 284
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
    pfam05783
    Location:26 → 493
    DLIC; Dynein light intermediate chain (DLIC)
    cl21455
    Location:46 → 101
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    44674956..44704877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166450.5 → XP_005166507.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDX2
    Conserved Domains (3) summary
    cd00882
    Location:219 → 284
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
    pfam05783
    Location:26 → 465
    DLIC; Dynein light intermediate chain (DLIC)
    cl21455
    Location:46 → 101
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394706.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    171180..198206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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