creb1a cAMP responsive element binding protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: creb1aprovided by ZNC
Official Full Name: cAMP responsive element binding protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-750
See related: Ensembl:ENSDARG00000053586 AllianceGenome:ZFIN:ZDB-GENE-040426-750
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: creb1; zgc:55598
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cAMP response element binding activity. Acts upstream of or within convergent extension involved in axis elongation; midbrain-hindbrain boundary development; and somitogenesis. Predicted to be located in nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Is expressed in nervous system; presumptive neural retina; and proliferative region. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (33547532..33557843, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (32814964..32825275, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
Title: CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fi76b09.y1 (e-PCR)
- UniSTS:198001

fc24h07.y1 (e-PCR)
- UniSTS:193223

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ATF4-CREB1 transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclic AMP-responsive element-binding protein 1a

Names: cAMP responsive element binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200909.1 → NP_957203.1 cyclic AMP-responsive element-binding protein 1a

See identical proteins and their annotated locations for NP_957203.1

Status: PROVISIONAL

Source sequence(s)

BC044436

UniProtKB/TrEMBL

A0A2R8QHW7, B2GNV9, Q803K8

Related

ENSDARP00000070114.5, ENSDART00000075632.6

Conserved Domains (2) summary

cd14690
Location:262 → 316

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:91 → 131

pKID; pKID domain