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esrp2 epithelial splicing regulatory protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 572992, updated on 4-Jan-2025

Summary

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Official Symbol
esrp2provided by ZNC
Official Full Name
epithelial splicing regulatory protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9824
See related
Ensembl:ENSDARG00000018814 AllianceGenome:ZFIN:ZDB-GENE-030131-9824
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb404; rbm35b; fa07a06; rbm35ba; sb:cb404; zgc:77254
Summary
Predicted to enable mRNA binding activity. Acts upstream of or within cranial skeletal system development and hard palate morphogenesis. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including EVL; anterior axial hypoblast; digestive system; neurogenic placode; and pleuroperitoneal region. Orthologous to human ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See esrp2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (34794829..34821836)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (34523352..34550359)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkey-148a17.5 Neighboring gene si:dkey-148a17.6 Neighboring gene nuclear factor of activated T cells 3a Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish genetic map with 2000 microsatellite markers. Shimoda N, et al. Genomics, 1999 Jun 15. PMID 10373319
  2. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
  3. An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Carroll SH, et al. Development, 2020 Dec 23. PMID 33234718, Free PMC Article
  4. On the tubulin polymerization promoting proteins of zebrafish. Orosz F. Biochem Biophys Res Commun, 2015 Feb 13. PMID 25576359
  5. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • FLJ20171, MGC55721, MGC77254

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cranial skeletal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hard palate morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epithelial splicing regulatory protein 2
Names
RNA-binding motif protein 35B
RNA-binding protein 35B
RNA-binding protein 35B-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199272.1 → NP_954966.1  epithelial splicing regulatory protein 2

    See identical proteins and their annotated locations for NP_954966.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045439
    UniProtKB/Swiss-Prot
    Q6P0A9, Q7ZVR8
    Related
    ENSDARP00000015568.9, ENSDART00000009698.11
    Conserved Domains (6) summary
    cd12254
    Location:661 → 732
    RRM_hnRNPH_ESRPs_RBM12_like; RNA recognition motif found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins
    cd12740
    Location:309 → 415
    RRM2_ESRP2; RNA recognition motif 2 in epithelial splicing regulatory protein 2 (ESRP2) and similar proteins
    cd12742
    Location:449 → 529
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:8 → 165
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:225 → 304
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl23807
    Location:572 → 658
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    34794829..34821836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168987.5 → XP_005169044.1  epithelial splicing regulatory protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005169044.1

    UniProtKB/Swiss-Prot
    Q6P0A9, Q7ZVR8
    UniProtKB/TrEMBL
    A0A8M2BGX1, G1K2P5
    Related
    ENSDARP00000069574.4, ENSDART00000075089.6
    Conserved Domains (4) summary
    cd12740
    Location:309 → 415
    RRM2_ESRP2; RNA recognition motif 2 in epithelial splicing regulatory protein 2 (ESRP2) and similar proteins
    cd12742
    Location:449 → 529
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:8 → 165
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:225 → 304
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_005168986.2 → XP_005169043.1  epithelial splicing regulatory protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P0A9, Q7ZVR8
    UniProtKB/TrEMBL
    A0A8M2BGB5
    Conserved Domains (5) summary
    cd12254
    Location:660 → 731
    RRM_hnRNPH_ESRPs_RBM12_like; RNA recognition motif found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins
    cd12740
    Location:308 → 414
    RRM2_ESRP2; RNA recognition motif 2 in epithelial splicing regulatory protein 2 (ESRP2) and similar proteins
    cd12742
    Location:448 → 528
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:8 → 165
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:224 → 303
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_017356901.3 → XP_017212390.1  epithelial splicing regulatory protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q6P0A9, Q7ZVR8
    UniProtKB/TrEMBL
    A0A8M6Z7Q3
    Conserved Domains (4) summary
    cd12740
    Location:309 → 415
    RRM2_ESRP2; RNA recognition motif 2 in epithelial splicing regulatory protein 2 (ESRP2) and similar proteins
    cd12742
    Location:449 → 529
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:8 → 165
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:225 → 304
    RRM_SF; RNA recognition motif (RRM) superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394699.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    58638..85645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVR8.2 GenPept UniProtKB/Swiss-Prot:Q7ZVR8

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