U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Or4e1 olfactory receptor family 4 subfamily E member 1 [ Mus musculus (house mouse) ]

Gene ID: 57270, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Or4e1provided by MGI
Official Full Name
olfactory receptor family 4 subfamily E member 1provided by MGI
Primary source
MGI:MGI:3031342
See related
Ensembl:ENSMUSG00000057564 AllianceGenome:MGI:3031342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Or10; Mor10; MOR244-2; MOR244-4; Olfr1508
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Or4e1 in Genome Data Viewer
Location:
14 C2; 14 26.95 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52700178..52704918, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52462721..52467461, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha variable 1 Neighboring gene olfactory receptor family 4 subfamily E member 2 Neighboring gene T cell receptor alpha chain Neighboring gene predicted gene, 36382 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene olfactory receptor family 4 subfamily E member 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutually exclusive expression of odorant receptor transgenes. Serizawa S, et al. Nat Neurosci, 2000 Jul. PMID 10862701
  2. Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Serizawa S, et al. Science, 2003 Dec 19. PMID 14593185
  3. Olfactory neurons expressing closely linked and homologous odorant receptor genes tend to project their axons to neighboring glomeruli on the olfactory bulb. Tsuboi A, et al. J Neurosci, 1999 Oct 1. PMID 10493742, Free PMC Article
  4. Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb. Takeuchi H, et al. Cell, 2010 Jun 11. PMID 20550939
  5. Emx2 stimulates odorant receptor gene expression. McIntyre JC, et al. Chem Senses, 2008 Nov. PMID 18854508, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of smell ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
odorant receptor MOR10
Names
GA_x6K02T2RJGY-520647-521579
gene for odorant receptor MOR10
olfactory receptor 1508
olfactory receptor MOR244-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007044.1 

    Range
    35255..39995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020513.3 → NP_065259.1  odorant receptor MOR10

    See identical proteins and their annotated locations for NP_065259.1

    Status: VALIDATED

    Source sequence(s)
    AC126025
    Consensus CDS
    CCDS27061.1
    UniProtKB/TrEMBL
    Q9R0K4
    Related
    ENSMUSP00000145649.2, ENSMUST00000206520.3
    Conserved Domains (2) summary
    pfam00001
    Location:44 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34 → 305
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52700178..52704918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools