Retnlb resistin like beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Retnlbprovided by MGI
Official Full Name: resistin like betaprovided by MGI
Primary source: MGI:MGI:1888505
See related: Ensembl:ENSMUSG00000022650 AllianceGenome:MGI:1888505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Xcp3; Fizz2; Relmb; RELMbeta; 9030012B21Rik
Summary: Predicted to enable hormone activity. Acts upstream of or within response to bacterium. Located in extracellular region. Is expressed in several structures, including brown fat; genitourinary system; intestine; liver; and spleen. Orthologous to human RETNLB (resistin like beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward colon adult (RPKM 34.9) See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 30.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (48637219..48639255)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (48816856..48818892)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

promotes host-bacterial mutualism by regulating the spatial segregation between the microbiota and the intestinal epithelium
Title: Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium.
The goblet cell-derived RELM-beta drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.
Title: The goblet cell-derived mediator RELM-β drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.
lack of RELMbeta leads to increased colonic expression of T helper cell type-2 cytokines and IL-17, associated with a reduced ability to maintain intestinal homeostasis
Title: Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retnlβ (RELMβ) Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility.
These data suggest the contribution of increases in RELMbeta in the gut and Kupffer cells to NASH development, raising the possibility of RELMbeta being a novel therapeutic target for NASH.
Title: Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.
These data demonstrate that RELMalpha but not RELMbeta significantly impacts the immune response to N. brasiliensis infection by downregulating the Th2 adaptive immune response in the lung.
Title: Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection.
RELMbeta protein levels were upregulated in Angiotensin II-induced Abdominal aortic aneurysm mice.Immunohistochemical staining revealed abundant expression of RELMbeta in AAA group, with scarce expression with saline treatment animals.
Title: Association of resistin-like molecule β levels and abdominal aortic aneurysm.
findings demonstrate that RELM-beta and goblet cells play an unexpected, yet critical role in recruiting CD4+ T cells to the colon to protect against an enteric pathogen
Title: Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation.
elevated RELM-beta expression in asthmatic airways contributes to airways remodelling at least partly by increasing fibroblast proliferation and differentiation with resulting deposition of extracellular matrix proteins.
Title: Resistin-like molecule-β (RELM-β) targets airways fibroblasts to effect remodelling in asthma: from mouse to man.
RELMbeta is abundantly expressed in foam cells within plaques and contributes to atherosclerosis development via lipid accumulation and inflammatory facilitation.
Title: Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development.
a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMbeta production
Title: Murine guanylate cyclase C regulates colonic injury and inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: resistin-like beta

Names: cysteine-rich secreted protein A12-beta; cysteine-rich secreted protein FIZZ2; found in inflammatory zone 2; resistin-like molecule beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.