Cldn13 claudin 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cldn13provided by MGI
Official Full Name: claudin 13provided by MGI
Primary source: MGI:MGI:1913102
See related: Ensembl:ENSMUSG00000008843 AllianceGenome:MGI:1913102
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2500004B14Rik
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a developmentally expressed renal tight junction protein. This gene is expressed in the cecum, colon, liver and kidney of mice, but is not identified in rat tissues. Humans and chimpanzees lack this gene. [provided by RefSeq, Aug 2010]
Expression: Biased expression in liver E14.5 (RPKM 92.8), liver E14 (RPKM 85.7) and 3 other tissues See more
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Genomic context

Location:: 5 G2; 5 74.88 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (134943104..134944384, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (134914250..134915530, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLDN13 is a constituent of Sertoli cell tight junctions. CLDN13 is expressed throughout the seminiferous cycle and is localized to bicellular tight junctions.
Title: Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.
Cldn13 is regulated as part of a stress induced erythropoiesis pathway and is expressed in tissues associated with haematopoietic function.
Title: Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis.
developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13
Title: Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Markers

PMC99911P5 (e-PCR)
- UniSTS:273702

NoName (e-PCR)
- UniSTS:235334

NoName (e-PCR)
- UniSTS:493127

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metallopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: claudin-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020504.4 → NP_065250.1 claudin-13

Status: REVIEWED

Source sequence(s)

AK010869, BY079003

Consensus CDS

CCDS39314.1

UniProtKB/Swiss-Prot

Q9Z0S4

UniProtKB/TrEMBL

Q547B2

Related

ENSMUSP00000008987.5, ENSMUST00000008987.5

Conserved Domains (1) summary

cl21598
Location:9 → 150

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family