nradd neurotrophin receptor associated death domain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nraddprovided by ZNC
Official Full Name: neurotrophin receptor associated death domainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2537
See related: Ensembl:ENSDARG00000057143 AllianceGenome:ZFIN:ZDB-GENE-030131-2537
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ngfr; wu:fb38c02; wu:fc10h01
Summary: Predicted to enable coreceptor activity; death receptor activity; and nerve growth factor binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (16316942..16341058, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (16408930..16433357, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The evolved divergence of gamma-secretase-susceptibility of homologous proteins Ngfrb and Nradd in zebrafish.
Title: The evolved divergence of γ-secretase-susceptibility of homologous proteins Ngfrb and Nradd in zebrafish.
Nradd Acts as a Negative Feedback Regulator of Wnt/beta-Catenin Signaling and Promotes Apoptosis.
Title: Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis.

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General gene information

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Markers

AI629342 (e-PCR)
- UniSTS:206117

fb38c02.x1 (e-PCR)
- UniSTS:203166

fc10h01.x1 (e-PCR)
- UniSTS:192474

AI437140 (e-PCR)
- UniSTS:206585

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables death receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nerve growth factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 16

Names: NGFRb; nerve growth factor receptor (TNFR superfamily, member 16)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

16316942..16341058 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_695893.9 → XP_700985.3 tumor necrosis factor receptor superfamily member 16

UniProtKB/TrEMBL

A0A8N7T743, E7F8D4

Related

ENSDARP00000002813.8, ENSDART00000022685.9

Conserved Domains (2) summary

cd08311
Location:326 → 404

Death_p75NR; Death domain of p75 Neurotrophin Receptor

cd13416
Location:23 → 184

TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271