tnrc6a trinucleotide repeat containing adaptor 6A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnrc6aprovided by ZNC
Official Full Name: trinucleotide repeat containing adaptor 6Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2519
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-2519
Gene type: pseudo
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc10d10
Summary: Acts upstream of or within negative regulation of translation and nuclear-transcribed mRNA poly(A) tail shortening. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6. Orthologous to human TNRC6A (trinucleotide repeat containing adaptor 6A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (35531069..35531511)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (35401561..35402003)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNA fate modulators are required for inhibition of translation by the tethered Mid domain of zebrafish TNRC6.
Title: Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast.
TNRC6A Induces Translational Inhibition and Deadenylation Through the Mid Domain in Zebrafish Embryos.
Title: Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.