U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

glis3 GLIS family zinc finger 3 [ Danio rerio (zebrafish) ]

Gene ID: 571000, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
glis3provided by ZNC
Official Full Name
GLIS family zinc finger 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-2232
See related
Ensembl:ENSDARG00000069726 AllianceGenome:ZFIN:ZDB-GENE-070112-2232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa55a05; zgc:158249
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in smoothened signaling pathway and thyroid gland development. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in nucleus. Is expressed in several structures, including brain; endoderm; otic vesicle; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See glis3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (643684..690223, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (628141..674274, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene SMAD family member 4a Neighboring gene regulatory factor X, 3 (influences HLA class II expression) Neighboring gene uncharacterized LOC137496532 Neighboring gene unc-5 netrin receptor Cb Neighboring gene bone morphogenetic protein receptor, type IBb

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GLIS3 and Thyroid: A Pleiotropic Candidate Gene for Congenital Hypothyroidism. Rurale G, et al. Front Endocrinol (Lausanne), 2018. PMID 30555422, Free PMC Article
  2. Identification and expression analysis of zebrafish polypeptide α-N-acetylgalactosaminyltransferase Y-subfamily genes during embryonic development. Nakayama Y, et al. Gene Expr Patterns, 2014 Sep. PMID 25026003
  3. Glis3 as a Critical Regulator of Thyroid Primordium Specification. Rurale G, et al. Thyroid, 2020 Feb. PMID 31797737
  4. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
  5. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glis3 as a Critical Regulator of Thyroid Primordium Specification.
    Title: Glis3 as a Critical Regulator of Thyroid Primordium Specification.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pancreas regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thyroid gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein GLIS3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080607.2 → NP_001074076.2  zinc finger protein GLIS3

    Status: VALIDATED

    Source sequence(s)
    BC129173, CA470456, CD585814, CU468737, DV591821
    UniProtKB/TrEMBL
    A0A8M1NCX8, A1L1Q6, F1QB13
    Related
    ENSDARP00000118619.1, ENSDART00000142833.2
    Conserved Domains (2) summary
    sd00017
    Location:469 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:483 → 510
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    643684..690223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305042.4 → XP_009303317.1  zinc finger protein GLIS3 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B5Y0, A1L1Q6
    Conserved Domains (2) summary
    sd00017
    Location:468 → 490
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:482 → 509
    zf-H2C2_2; Zinc-finger double domain

  2. XM_021479194.2 → XP_021334869.1  zinc finger protein GLIS3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q669, A1L1Q6
    Conserved Domains (2) summary
    COG5189
    Location:458 → 552
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:469 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_017357981.3 → XP_017213470.1  zinc finger protein GLIS3 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z1B7, A1L1Q6

  4. XM_021479193.2 → XP_021334868.1  zinc finger protein GLIS3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q669, A1L1Q6
    Conserved Domains (2) summary
    COG5189
    Location:458 → 552
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:469 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools