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letm1 leucine zipper-EF-hand containing transmembrane protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 570745, updated on 2-Nov-2024

Summary

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Official Symbol
letm1provided by ZNC
Official Full Name
leucine zipper-EF-hand containing transmembrane protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-154
See related
Ensembl:ENSDARG00000056978 AllianceGenome:ZFIN:ZDB-GENE-050522-154
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
KHE; fc31h08; fc58h01; wu:fc31h08; wu:fc58h01; zgc:109969
Summary
Predicted to enable calcium:proton antiporter activity. Predicted to be involved in several processes, including calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and protein complex oligomerization. Predicted to act upstream of or within calcium ion transport and potassium ion transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See letm1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13033838..13100624)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (12901362..12970404)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438971 Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene fibroblast growth factor receptor 3 Neighboring gene uncharacterized LOC108191973

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling. Sun X, et al. Theranostics, 2020. PMID 32641982, Free PMC Article
  2. The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. Dao P, et al. Life Sci Alliance, 2022 Sep. PMID 35697381, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish.
    Title: The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109969, MGC191626

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium export from the mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in inner mitochondrial membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein hexamerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial proton/calcium exchanger protein
Names
LETM1 and EF-hand domain-containing protein 1, mitochondrial
electroneutral mitochondrial K(+)/H(+)exchanger
let-m1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045208.1 → NP_001038673.1  mitochondrial proton/calcium exchanger protein

    See identical proteins and their annotated locations for NP_001038673.1

    Status: PROVISIONAL

    Source sequence(s)
    BX119973
    UniProtKB/Swiss-Prot
    B8JIA3, Q1LY46
    Related
    ENSDARP00000074011.5, ENSDART00000079558.7
    Conserved Domains (3) summary
    pfam07766
    Location:162 → 417
    LETM1; LETM1-like protein
    cl01888
    Location:579 → 639
    DUF883; Bacterial protein of unknown function (DUF883)
    cl23750
    Location:473 → 604
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    13033838..13100624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212916.1 → XP_068069017.1  mitochondrial proton/calcium exchanger protein isoform X4

    Related
    ENSDARP00000131431.1, ENSDART00000159441.3

  2. XM_009307182.3 → XP_009305457.1  mitochondrial proton/calcium exchanger protein isoform X5

    UniProtKB/Swiss-Prot
    B8JIA3, Q1LY46
    UniProtKB/TrEMBL
    A0A8M3AYW7
    Conserved Domains (2) summary
    pfam07766
    Location:162 → 417
    LETM1; LETM1-like protein
    cl01888
    Location:590 → 650
    DUF883; Bacterial protein of unknown function (DUF883)

  3. XM_009307180.3 → XP_009305455.1  mitochondrial proton/calcium exchanger protein isoform X1

    UniProtKB/Swiss-Prot
    B8JIA3, Q1LY46
    UniProtKB/TrEMBL
    A0A8M3AYY0
    Conserved Domains (2) summary
    pfam07766
    Location:162 → 417
    LETM1; LETM1-like protein
    cl01888
    Location:590 → 650
    DUF883; Bacterial protein of unknown function (DUF883)

  4. XM_009307181.3 → XP_009305456.1  mitochondrial proton/calcium exchanger protein isoform X2

    UniProtKB/Swiss-Prot
    B8JIA3, Q1LY46
    UniProtKB/TrEMBL
    A0A8M3BEI6
    Conserved Domains (2) summary
    pfam07766
    Location:162 → 417
    LETM1; LETM1-like protein
    cl01888
    Location:590 → 650
    DUF883; Bacterial protein of unknown function (DUF883)

  5. XM_005156569.4 → XP_005156626.1  mitochondrial proton/calcium exchanger protein isoform X3

    UniProtKB/Swiss-Prot
    B8JIA3, Q1LY46
    UniProtKB/TrEMBL
    A0A8M2B3G3
    Conserved Domains (3) summary
    pfam07766
    Location:162 → 417
    LETM1; LETM1-like protein
    cl01888
    Location:579 → 639
    DUF883; Bacterial protein of unknown function (DUF883)
    cl23750
    Location:473 → 604
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395307.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    88398..148507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1LY46.2 GenPept UniProtKB/Swiss-Prot:Q1LY46

Gene LinkOut

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