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urb2 URB2 ribosome biogenesis homolog [ Danio rerio (zebrafish) ]

Gene ID: 570267, updated on 9-Dec-2024

Summary

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Official Symbol
urb2provided by ZNC
Official Full Name
URB2 ribosome biogenesis homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2621
See related
Ensembl:ENSDARG00000003217 AllianceGenome:ZFIN:ZDB-GENE-030131-2621
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc13e02; wu:fc13e02; si:dkey-162b3.2
Summary
Involved in regulation of signal transduction by p53 class mediator. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in caudal hematopoietic tissue. Orthologous to human URB2 (URB2 ribosome biogenesis homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See urb2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24234330..24262839, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24103882..24130159, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene piggyBac transposable element derived 5 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 10 Neighboring gene actin alpha 1, skeletal muscle b Neighboring gene centriole, cilia and spindle-associated protein b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Huang W, et al. Stem Cell Reports, 2024 Sep 10. PMID 39178846, Free PMC Article
  2. Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Cai P, et al. Biochem Biophys Res Commun, 2018 Mar 4. PMID 29470984
  3. Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. Sztal TE, et al. PLoS Genet, 2018 Feb. PMID 29420541, Free PMC Article
  4. Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration. He J, et al. Hepatology, 2019 Dec. PMID 31136010
  5. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish.
    Title: mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish.
  2. Loss of Urb2 disrupts definitive hematopoiesis in zebrafish.
    Title: Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • KIAA0133

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unhealthy ribosome biogenesis protein 2 homolog
Names
URB2 ribosome biogenesis 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123301.2 → NP_001116773.2  unhealthy ribosome biogenesis protein 2 homolog isoform 1

    See identical proteins and their annotated locations for NP_001116773.2

    Status: PROVISIONAL

    Source sequence(s)
    CR762497
    UniProtKB/Swiss-Prot
    B0V0U5
    Related
    ENSDARP00000121235.1, ENSDART00000138747.3
    Conserved Domains (1) summary
    pfam10441
    Location:1291 → 1484
    Urb2; Urb2/Npa2 family

  2. NM_001123393.1 → NP_001116865.1  unhealthy ribosome biogenesis protein 2 homolog isoform 2

    Status: PROVISIONAL

    Source sequence(s)
    CR762497
    UniProtKB/TrEMBL
    A0A8N7UYV9, B0V0U6, F1QES6
    Related
    ENSDARP00000123082.1, ENSDART00000146524.2
    Conserved Domains (1) summary
    pfam10441
    Location:122 → 315
    Urb2; Urb2/Npa2 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    24234330..24262839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212915.1 → XP_068069016.1  unhealthy ribosome biogenesis protein 2 homolog isoform X1

    Related
    ENSDARP00000144441.2, ENSDART00000176800.2

  2. XM_005156878.5 → XP_005156935.1  unhealthy ribosome biogenesis protein 2 homolog isoform X2

    See identical proteins and their annotated locations for XP_005156935.1

    UniProtKB/Swiss-Prot
    B0V0U5
    Conserved Domains (1) summary
    pfam10441
    Location:1291 → 1484
    Urb2; Urb2/Npa2 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0V0U5.1 GenPept UniProtKB/Swiss-Prot:B0V0U5

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