itgb1b integrin, beta 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itgb1bprovided by ZNC
Official Full Name: integrin, beta 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030909-10
See related: Ensembl:ENSDARG00000104484 AllianceGenome:ZFIN:ZDB-GENE-030909-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb810; itgb1
Summary: Enables protein heterodimerization activity. Involved in cell adhesion mediated by integrin and endothelial cell-matrix adhesion via fibronectin. Acts upstream of or within several processes, including Kupffer's vesicle development; cell migration involved in gastrulation; and striated muscle cell development. Predicted to be located in several cellular components, including lamellipodium; melanosome; and ruffle membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface; focal adhesion; and synapse. Is expressed in several structures, including cardiovascular system; digestive system; mesoderm; muscle; and pleuroperitoneal region. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (43577293..43583881, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003334166.1 (624..7222, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An integrin beta1b mutant zebrafish exhibited morphological abnormalities in blood vessel formation, cephalic hemorrhage and a decreased responsiveness to tactile stimulation during development.
Title: Integrin β1 activity is required for cardiovascular formation in zebrafish.
Contrary to the C terminus of proteins that engage PDZ domains, the C-terminal three residues of beta1, per se, do not contribute to kindlin-2 binding or to laterality organ development.
Title: C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.
The duplication that gave rise to beta1-1 and beta1-2 occurred after the divergence of the tetrapod & fish lineages. Beta1-1 & beta1-2 may share the roles of the solitary beta1 subunit in other vertebrates. integrin beta 1-2.
Title: Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Markers

fc70d09.y1 (e-PCR)
- UniSTS:194307

fc27g07.x1 (e-PCR)
- UniSTS:193375

fc27g07.x1 (e-PCR)
- UniSTS:193376

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding involved in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endothelial cell-matrix adhesion via fibronectin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: integrin beta-1b

Names: beta1-2; cr3; integrin beta1 subunit-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034987.1 → NP_001030159.1 integrin beta-1b precursor

See identical proteins and their annotated locations for NP_001030159.1

Status: PROVISIONAL

Source sequence(s)

DQ149102

UniProtKB/TrEMBL

Q3YAA0

Related

ENSDARP00000137182.2, ENSDART00000161711.2

Conserved Domains (3) summary

pfam00362
Location:31 → 461

Integrin_beta; Integrin, beta chain

pfam07965
Location:637 → 724

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:754 → 792

Integrin_b_cyt; Integrin beta cytoplasmic domain