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ggt5a gamma-glutamyltransferase 5a [ Danio rerio (zebrafish) ]

Gene ID: 569734, updated on 9-Dec-2024

Summary

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Official Symbol
ggt5aprovided by ZNC
Official Full Name
gamma-glutamyltransferase 5aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080226-1
See related
Ensembl:ENSDARG00000052045 AllianceGenome:ZFIN:ZDB-GENE-080226-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ggt5
Summary
Predicted to enable glutathione hydrolase activity and leukotriene-C(4) hydrolase. Predicted to be involved in glutathione catabolic process; inflammatory response; and leukotriene D4 biosynthetic process. Predicted to be active in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ggt5a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (39998507..40028441)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (39964722..39995239)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 1a Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene gamma-glutamyltransferase 1a Neighboring gene leucine rich repeat containing 75Ba Neighboring gene uncharacterized LOC137496378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative genomics of duplicate γ-glutamyl transferase genes in teleosts: medaka (Oryzias latipes), stickleback (Gasterosteus aculeatus), green spotted pufferfish (Tetraodon nigroviridis), fugu (Takifugu rubripes), and zebrafish (Danio rerio). Law SH, et al. J Exp Zool B Mol Dev Evol, 2012 Jan 15. PMID 21898790, Free PMC Article
  2. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Timme-Laragy AR, et al. Free Radic Biol Med, 2013 Dec. PMID 23770340, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C(4) hydrolase IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene D4 biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-glutamyltransferase 5a
Names
gamma-glutamyltransferase 5
ggtla1
NP_001116770.1
XP_005167440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123298.1 → NP_001116770.1  gamma-glutamyltransferase 5a

    Status: PROVISIONAL

    Source sequence(s)
    CR388077
    UniProtKB/TrEMBL
    A0A8M1NIH9, B0UXV4
    Related
    ENSDARP00000116811.1, ENSDART00000134452.2
    Conserved Domains (1) summary
    cl19223
    Location:58 → 508
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    39998507..40028441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167383.5 → XP_005167440.1  gamma-glutamyltransferase 5a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BET1, E9QDV5
    Related
    ENSDARP00000068272.5, ENSDART00000073782.8
    Conserved Domains (1) summary
    pfam01019
    Location:58 → 551
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein Strain
Heading Accession and Version

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