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mgaa MAX dimerization protein MGA a [ Danio rerio (zebrafish) ]

Gene ID: 569620, updated on 4-Jan-2025

Summary

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Official Symbol
mgaaprovided by ZNC
Official Full Name
MAX dimerization protein MGA aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030603-1
See related
Ensembl:ENSDARG00000078784 AllianceGenome:ZFIN:ZDB-GENE-030603-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mga; sb:eu601; im:7137698; wu:fd99g02
Summary
Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including SMAD protein signal transduction; determination of bilateral symmetry; and positive regulation of BMP signaling pathway. Part of SMAD protein complex. Is expressed in several structures, including gut; head; pectoral fin bud; and yolk syncytial layer. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See mgaa in Genome Data Viewer
Location:
chromosome: 17
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (10566501..10588337)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (10410364..10432307)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene mirror-image polydactyly 1 Neighboring gene TYRO3 protein tyrosine kinase Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene jumonji domain containing 7 Neighboring gene golgin subfamily A member 6-like protein 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga. Lardelli M. Dev Genes Evol, 2003 Oct. PMID 12908107
  2. Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives. Wang D, et al. Environ Pollut, 2020 Oct. PMID 32554097
  3. Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish. Sun X, et al. Front Cell Dev Biol, 2018. PMID 30324105, Free PMC Article
  4. Extraembryonic signals under the control of MGA, Max, and Smad4 are required for dorsoventral patterning. Sun Y, et al. Dev Cell, 2014 Feb 10. PMID 24525188
  5. Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish. Windner SE, et al. Biol Open, 2012 Aug 15. PMID 23213474, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. functions early to influence key regulators of mesendoderm, including tbx6, cas, sox17
    Title: The tbx/bHLH transcription factor mga regulates gata4 and organogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of ventral identity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of ventral identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SMAD protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAX dimerization protein MGA a
Names
MAX gene associated a
MGA, MAX dimerization protein a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170739.1 → NP_001164210.1  MAX dimerization protein MGA a

    See identical proteins and their annotated locations for NP_001164210.1

    Status: PROVISIONAL

    Source sequence(s)
    GU122854
    UniProtKB/TrEMBL
    D2JVK2
    Related
    ENSDARP00000099539.2, ENSDART00000110593.4
    Conserved Domains (2) summary
    pfam00907
    Location:102 → 284
    T-box; T-box
    pfam16059
    Location:1321 → 1366
    DUF4801; Domain of unknown function (DUF4801)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    10566501..10588337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158619.5 → XP_005158676.1  MAX dimerization protein MGA a isoform X1

    See identical proteins and their annotated locations for XP_005158676.1

    UniProtKB/TrEMBL
    A0A2R8PZ52, A0A8M2B5I7
    Related
    ENSDARP00000122330.2, ENSDART00000137469.4
    Conserved Domains (3) summary
    pfam00907
    Location:102 → 284
    T-box; T-box
    pfam15458
    Location:2131 → 2271
    NTR2; Nineteen complex-related protein 2
    pfam16059
    Location:1321 → 1366
    DUF4801; Domain of unknown function (DUF4801)

  2. XM_005158621.5 → XP_005158678.1  MAX dimerization protein MGA a isoform X3

    UniProtKB/TrEMBL
    A0A8M2B523
    Conserved Domains (2) summary
    pfam00907
    Location:102 → 284
    T-box; T-box
    pfam16059
    Location:1321 → 1366
    DUF4801; Domain of unknown function (DUF4801)

  3. XM_005158623.5 → XP_005158680.1  MAX dimerization protein MGA a isoform X4

    UniProtKB/TrEMBL
    A0A8M2B518
    Conserved Domains (3) summary
    pfam00907
    Location:102 → 284
    T-box; T-box
    pfam15458
    Location:2104 → 2244
    NTR2; Nineteen complex-related protein 2
    pfam16059
    Location:1321 → 1366
    DUF4801; Domain of unknown function (DUF4801)

  4. XM_005158622.5 → XP_005158679.1  MAX dimerization protein MGA a isoform X2

    UniProtKB/TrEMBL
    A0A8M2B516
    Conserved Domains (3) summary
    pfam00907
    Location:102 → 284
    T-box; T-box
    pfam15458
    Location:2130 → 2270
    NTR2; Nineteen complex-related protein 2
    pfam16059
    Location:1321 → 1366
    DUF4801; Domain of unknown function (DUF4801)

  5. XM_005158624.5 → XP_005158681.1  MAX dimerization protein MGA a isoform X5

    UniProtKB/TrEMBL
    A0A8M2B5K5, F1R7N7
    Conserved Domains (3) summary
    pfam00907
    Location:102 → 284
    T-box; T-box
    pfam15458
    Location:2028 → 2168
    NTR2; Nineteen complex-related protein 2
    pfam16059
    Location:1321 → 1366
    DUF4801; Domain of unknown function (DUF4801)

  6. XM_005158620.5 → XP_005158677.1  MAX dimerization protein MGA a isoform X1

    See identical proteins and their annotated locations for XP_005158677.1

    UniProtKB/TrEMBL
    A0A2R8PZ52, A0A8M2B5I7
    Related
    ENSDARP00000145285.1, ENSDART00000182371.1
    Conserved Domains (3) summary
    pfam00907
    Location:102 → 284
    T-box; T-box
    pfam15458
    Location:2131 → 2271
    NTR2; Nineteen complex-related protein 2
    pfam16059
    Location:1321 → 1366
    DUF4801; Domain of unknown function (DUF4801)
Nucleotide Protein Strain
Heading Accession and Version

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