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fxyd11 FXYD domain containing ion transport regulator 11 [ Danio rerio (zebrafish) ]

Gene ID: 569335, updated on 9-Dec-2024

Summary

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Official Symbol
fxyd11provided by ZNC
Official Full Name
FXYD domain containing ion transport regulator 11provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-33
See related
Ensembl:ENSDARG00000099117 AllianceGenome:ZFIN:ZDB-GENE-030131-33
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zeh0312; hm:zeh0312; si:dkey-33i11.4
Summary
Predicted to enable ion channel regulator activity. Predicted to act upstream of or within monoatomic ion transport and regulation of monoatomic ion transport. Located in membrane. Is expressed in NaK ionocyte; gill; gill ionocyte; and gill lamella. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See fxyd11 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (45228098..45235932, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (45261382..45269216, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-33i11.9 Neighboring gene FXYD domain containing ion transport regulator 3 Neighboring gene hepsin Neighboring gene myelin-associated glycoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of zebrafish Fxyd11a protein that is highly expressed in ion-transporting epithelium of the gill and skin and its possible role in ion homeostasis. Saito K, et al. Front Physiol, 2010. PMID 21423371, Free PMC Article
  2. The zebrafish reference genome sequence and its relationship to the human genome. Howe K, et al. Nature, 2013 Apr 25. PMID 23594743, Free PMC Article
  3. Na(+) K(+) ATPase isoform switching in zebrafish during transition to dilute freshwater habitats. Esbaugh AJ, et al. Proc Biol Sci, 2019 May 29. PMID 31113326, Free PMC Article
  4. Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Ton C, et al. Genome Res, 2000 Dec. PMID 11116087, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ion channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FXYD domain-containing ion transport regulator 11
Names
FXYD domain containing ion transport regulator-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282018.1 → NP_001268947.1  FXYD domain-containing ion transport regulator 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001268947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    EH447516, EH457718
    UniProtKB/Swiss-Prot
    C0HJJ0
    UniProtKB/TrEMBL
    X5IY73
    Related
    ENSDARP00000137233.1, ENSDART00000164436.2
    Conserved Domains (1) summary
    pfam02038
    Location:21 → 63
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

  2. NM_001282020.1 → NP_001268949.1  FXYD domain-containing ion transport regulator 11 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    EH447516, EH449767
    UniProtKB/Swiss-Prot
    C0HJJ0
    Related
    ENSDART00000168966.2
    Conserved Domains (1) summary
    pfam02038
    Location:21 → 61
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    45228098..45235932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0HJJ0.1 GenPept UniProtKB/Swiss-Prot:C0HJJ0

Gene LinkOut

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Molecular Biology Databases
Research Materials