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GPR108 G protein-coupled receptor 108 [ Homo sapiens (human) ]

Gene ID: 56927, updated on 27-Nov-2024

Summary

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Official Symbol
GPR108provided by HGNC
Official Full Name
G protein-coupled receptor 108provided by HGNC
Primary source
HGNC:HGNC:17829
See related
Ensembl:ENSG00000125734 MIM:618491; AllianceGenome:HGNC:17829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LUSTR2
Summary
Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 21.4), duodenum (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

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See GPR108 in Genome Data Viewer
Location:
19p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6729914..6737580, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6719314..6726971, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6729925..6737591, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13854 Neighboring gene TNF superfamily member 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6674384-6674960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6674961-6675535 Neighboring gene Sharpr-MPRA regulatory region 11629 Neighboring gene complement C3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697003-6697504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697505-6698004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6727893-6728394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6728395-6728894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9961 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:6735174-6735942 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736406-6736560 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736926-6737087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6738248-6739016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6739785-6740552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6742783-6743702 Neighboring gene microRNA 6791 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6745754-6746254 Neighboring gene uncharacterized LOC124904623 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9967 Neighboring gene SH2 domain containing 3A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6760841-6761341 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6764936-6765836

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer. Lyu S, et al. Pharmacol Res, 2022 Aug. PMID 35659621
  2. GPR108 Is a Highly Conserved AAV Entry Factor. Dudek AM, et al. Mol Ther, 2020 Feb 5. PMID 31784416, Free PMC Article
  3. Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction. Meisen WH, et al. Mol Ther Methods Clin Dev, 2020 Jun 12. PMID 32280726, Free PMC Article
  4. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. Zhao M, et al. Cell Rep, 2023 Jun 27. PMID 37330913
  5. GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. Dong D, et al. PLoS One, 2018. PMID 30332431, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
    Title: A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
  2. GPR108 is required for gambogic acid inhibiting NF-kappaB signaling in cancer.
    Title: GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer.
  3. GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
    Title: GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
  4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Risk of meningioma and common variation in genes related to innate immunity.
  6. The 18-exon human GPR107 gene is located at 9q34.2-3 and spans 86.4 kb and the cDNA encodes a 552 residue protein; murine Gpr108 cDNA encodes a 562 residue protein that has 49% identity to human GPR107.
    Title: Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cis-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein GPR108
Names
lung seven transmembrane receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080452.2 → NP_001073921.1  protein GPR108 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001073921.1

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Consensus CDS
    CCDS42479.1
    UniProtKB/Swiss-Prot
    B9EJD7, Q9NPR9
    UniProtKB/TrEMBL
    A8K7F3
    Related
    ENSP00000264080.5, ENST00000264080.12
    Conserved Domains (1) summary
    pfam06814
    Location:215 → 503
    Lung_7-TM_R; Lung seven transmembrane receptor

  2. NM_001394714.1 → NP_001381643.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Consensus CDS
    CCDS45940.1
    UniProtKB/TrEMBL
    B9EK73, G5E9L6
    Conserved Domains (1) summary
    pfam06814
    Location:1 → 261
    Lung_7-TM_R; Lung seven transmembrane receptor

  3. NM_001394715.1 → NP_001381644.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Consensus CDS
    CCDS45940.1
    UniProtKB/TrEMBL
    B9EK73, G5E9L6
    Conserved Domains (1) summary
    pfam06814
    Location:1 → 261
    Lung_7-TM_R; Lung seven transmembrane receptor

  4. NM_001394716.1 → NP_001381645.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Consensus CDS
    CCDS45940.1
    UniProtKB/TrEMBL
    B9EK73, G5E9L6
    Conserved Domains (1) summary
    pfam06814
    Location:1 → 261
    Lung_7-TM_R; Lung seven transmembrane receptor

  5. NM_001394717.1 → NP_001381646.1  protein GPR108 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:216 → 418
    Lung_7-TM_R; Lung seven transmembrane receptor

  6. NM_001394718.1 → NP_001381647.1  protein GPR108 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    UniProtKB/TrEMBL
    A8K7F3
    Conserved Domains (1) summary
    pfam06814
    Location:216 → 503
    Lung_7-TM_R; Lung seven transmembrane receptor

  7. NM_001394719.1 → NP_001381648.1  protein GPR108 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    UniProtKB/TrEMBL
    A8K7F3
    Conserved Domains (1) summary
    pfam06814
    Location:216 → 450
    Lung_7-TM_R; Lung seven transmembrane receptor

  8. NM_001394720.1 → NP_001381649.1  protein GPR108 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    UniProtKB/TrEMBL
    A8K7F3
    Conserved Domains (1) summary
    pfam06814
    Location:216 → 487
    Lung_7-TM_R; Lung seven transmembrane receptor

  9. NM_001394721.1 → NP_001381650.1  protein GPR108 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    UniProtKB/TrEMBL
    A8K7F3
    Conserved Domains (1) summary
    pfam06814
    Location:199 → 486
    Lung_7-TM_R; Lung seven transmembrane receptor

  10. NM_001394722.1 → NP_001381651.1  protein GPR108 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    UniProtKB/TrEMBL
    A8K7F3
    Conserved Domains (1) summary
    pfam06814
    Location:216 → 478
    Lung_7-TM_R; Lung seven transmembrane receptor

  11. NM_001394723.1 → NP_001381652.1  protein GPR108 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    UniProtKB/TrEMBL
    A8K7F3
    Conserved Domains (1) summary
    pfam06814
    Location:216 → 450
    Lung_7-TM_R; Lung seven transmembrane receptor

  12. NM_001394724.1 → NP_001381653.1  protein GPR108 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1 → 176
    Lung_7-TM_R; Lung seven transmembrane receptor

  13. NM_001394725.1 → NP_001381654.1  protein GPR108 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1 → 208
    Lung_7-TM_R; Lung seven transmembrane receptor

  14. NM_001394726.1 → NP_001381655.1  protein GPR108 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1 → 208
    Lung_7-TM_R; Lung seven transmembrane receptor

  15. NM_001394727.1 → NP_001381656.1  protein GPR108 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC008760
    UniProtKB/TrEMBL
    B9EK73
    Conserved Domains (1) summary
    cl21735
    Location:1 → 236
    Lung_7-TM_R; Lung seven transmembrane receptor

  16. NM_001394728.1 → NP_001381657.1  protein GPR108 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1 → 208
    Lung_7-TM_R; Lung seven transmembrane receptor

  17. NM_020171.2 → NP_064556.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Consensus CDS
    CCDS45940.1
    UniProtKB/TrEMBL
    B9EK73, G5E9L6
    Related
    ENSP00000401284.2, ENST00000430424.8
    Conserved Domains (1) summary
    pfam06814
    Location:1 → 261
    Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6729914..6737580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439110.1 → XP_047295066.1  protein GPR108 isoform X1

    UniProtKB/TrEMBL
    G5E9L6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6719314..6726971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321503.1 → XP_054177478.1  protein GPR108 isoform X1

    UniProtKB/TrEMBL
    G5E9L6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPR9.3 GenPept UniProtKB/Swiss-Prot:Q9NPR9

Gene LinkOut

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