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angptl2a angiopoietin-like 2a [ Danio rerio (zebrafish) ]

Gene ID: 569092, updated on 9-Dec-2024

Summary

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Official Symbol
angptl2aprovided by ZNC
Official Full Name
angiopoietin-like 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080721-15
See related
Ensembl:ENSDARG00000024030 AllianceGenome:ZFIN:ZDB-GENE-080721-15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
angptl2b; zgc:194138; zgc:194145
Summary
Predicted to enable signaling receptor binding activity. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL2 (angiopoietin like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See angptl2a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (4797329..4829254)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (4372677..4403839)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cystatin-B-like Neighboring gene uncharacterized LOC110439800 Neighboring gene ras-specific guanine nucleotide-releasing factor RalGPS1-like Neighboring gene uncharacterized LOC137495547 Neighboring gene zinc finger and BTB domain containing 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiopoietin-related protein 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030230.1 → NP_001025401.1  angiopoietin-related protein 2a precursor

    See identical proteins and their annotated locations for NP_001025401.1

    Status: PROVISIONAL

    Source sequence(s)
    AB197679
    UniProtKB/TrEMBL
    B3DGJ4, Q4LES0
    Related
    ENSDARP00000067598.4, ENSDART00000067599.7
    Conserved Domains (3) summary
    cd00087
    Location:305 → 519
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:119 → 215
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam08961
    Location:50 → 147
    DUF1875; Domain of unknown function (DUF1875)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    4797329..4829254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168602.5 → XP_005168659.1  angiopoietin-related protein 2a isoform X1

    See identical proteins and their annotated locations for XP_005168659.1

    UniProtKB/TrEMBL
    B3DGJ4, Q4LES0
    Conserved Domains (3) summary
    cd00087
    Location:305 → 519
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:119 → 215
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam08961
    Location:50 → 147
    DUF1875; Domain of unknown function (DUF1875)
Nucleotide Protein
Heading Accession and Version

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