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reep2 receptor accessory protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 568927, updated on 4-Jan-2025

Summary

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Official Symbol
reep2provided by ZNC
Official Full Name
receptor accessory protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050706-125
See related
Ensembl:ENSDARG00000031382 AllianceGenome:ZFIN:ZDB-GENE-050706-125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110128
Summary
Predicted to enable microtubule binding activity and taste receptor binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization. Predicted to be located in membrane. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 72A. Orthologous to human REEP2 (receptor accessory protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See reep2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21596716..21618027, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (21299471..21320760, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487582 Neighboring gene early growth response 1 Neighboring gene lysine (K)-specific demethylase 3B Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. Lee SH, et al. Nat Commun, 2020 Feb 19. PMID 32075961, Free PMC Article
  2. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC110128

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taste receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor expression-enhancing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030227.1 → NP_001025398.1  receptor expression-enhancing protein 2

    See identical proteins and their annotated locations for NP_001025398.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098549
    UniProtKB/Swiss-Prot
    Q4KMI4
    Related
    ENSDARP00000043161.6, ENSDART00000043162.7
    Conserved Domains (1) summary
    pfam03134
    Location:7 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    21596716..21618027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173132.4 → XP_005173189.1  receptor expression-enhancing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BKF7
    Conserved Domains (1) summary
    pfam03134
    Location:7 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394903.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    416232..437521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KMI4.1 GenPept UniProtKB/Swiss-Prot:Q4KMI4

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