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Ifit1 interferon-induced protein with tetratricopeptide repeats 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56824, updated on 27-Nov-2024

Summary

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Official Symbol
Ifit1provided by RGD
Official Full Name
interferon-induced protein with tetratricopeptide repeats 1provided by RGD
Primary source
RGD:620599
See related
EnsemblRapid:ENSRNOG00000019050 AllianceGenome:RGD:620599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Garg16
Summary
Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See Ifit1 in Genome Data Viewer
Location:
1q53
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241565197..241567262)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (232152038..232154103)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252944105..252946170)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1B-like Neighboring gene solute carrier family 16, member 12 Neighboring gene uncharacterized LOC134485224

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia. Kitamura Y, et al. J Neurosci Res, 2001 Jun 15. PMID 11398178
  2. The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A. Li HT, et al. Mol Cell Biochem, 2010 Apr. PMID 19856081
  3. Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family. Bluyssen HA, et al. Genomics, 1994 Nov 1. PMID 7896268
  4. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
  5. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Daffis S, et al. Nature, 2010 Nov 18. PMID 21085181, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-induced protein with tetratricopeptide repeats 1-like protein
Names
glucocorticoid-attenuated response gene 16 product

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020096.1 → NP_064481.1  interferon-induced protein with tetratricopeptide repeats 1-like protein

    See identical proteins and their annotated locations for NP_064481.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ276893
    UniProtKB/TrEMBL
    A6I137, Q9JJT1
    Related
    ENSRNOP00000099636.1, ENSRNOT00000132040.1
    Conserved Domains (2) summary
    pfam04733
    Location:158 → 421
    Coatomer_E; Coatomer epsilon subunit
    sd00006
    Location:242 → 270
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    241565197..241567262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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