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dlc1 DLC1 Rho GTPase activating protein [ Danio rerio (zebrafish) ]

Gene ID: 567965, updated on 4-Jan-2025

Summary

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Official Symbol
dlc1provided by ZNC
Official Full Name
DLC1 Rho GTPase activating proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-130206-12
See related
Ensembl:ENSDARG00000079317 AllianceGenome:ZFIN:ZDB-GENE-130206-12
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable GTPase activator activity and lipid binding activity. Predicted to act upstream of or within lipid transport and signal transduction. Predicted to be located in focal adhesion and membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See dlc1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (15291025..15535544, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (14604512..14849057, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene uncharacterized LOC137495478 Neighboring gene uncharacterized LOC137495477 Neighboring gene sarcoglycan zeta Neighboring gene uncharacterized LOC137495479

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DLC1 Rho GTPase activating protein; rho GTPase-activating protein 7
Names
unm_sa1141

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    15291025..15535544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017355991.3 → XP_017211480.1  rho GTPase-activating protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z677

  2. XM_021476167.2 → XP_021331842.2  rho GTPase-activating protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PK49

  3. XM_005159860.4 → XP_005159917.1  rho GTPase-activating protein 7 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B6R6, A0A8M9PK49, E7FBY0
    Related
    ENSDARP00000103088.2, ENSDART00000109970.4
    Conserved Domains (4) summary
    cd09538
    Location:9 → 68
    SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
    smart00454
    Location:9 → 68
    SAM; Sterile alpha motif
    cd04375
    Location:679 → 900
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:931 → 1126
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Nucleotide Protein Strain
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