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agla amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase a [ Danio rerio (zebrafish) ]

Gene ID: 567798, updated on 4-Jan-2025

Summary

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Official Symbol
aglaprovided by ZNC
Official Full Name
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-071004-6
See related
Ensembl:ENSDARG00000103811 AllianceGenome:ZFIN:ZDB-GENE-071004-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
agl; si:ch211-153l6.1
Summary
Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to act upstream of or within glycogen biosynthetic process and glycogen catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See agla in Genome Data Viewer
Location:
chromosome: 2
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (20472149..20526835)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (20814143..20868863)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch211-153l6.6 Neighboring gene ferric-chelate reductase 1a Neighboring gene si:ch73-14h1.2 Neighboring gene si:ch211-267e7.3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. Quach HN, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840430, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4-alpha-glucanotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables amylo-alpha-1,6-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycogen debranching enzyme
Names
amylo-1, 6-glucosidase, 4-alpha-glucanotransferase a
NP_001166124.1
XP_005163674.1
XP_005163675.1
XP_009296758.1
XP_009296759.1
XP_009296760.1
XP_068080855.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172653.1 → NP_001166124.1  glycogen debranching enzyme

    Status: VALIDATED

    Source sequence(s)
    BX510644, CU928067
    UniProtKB/TrEMBL
    A0A0R4IV67, A0A8M1NUM0
    Related
    ENSDARP00000138992.1, ENSDART00000168537.2
    Conserved Domains (5) summary
    cd11327
    Location:105 → 583
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:21 → 1532
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1073 → 1527
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:30 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:697 → 974
    hGDE_central; central domain of human glycogen debranching enzyme

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    20472149..20526835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298484.4 → XP_009296759.1  glycogen debranching enzyme isoform X1

    See identical proteins and their annotated locations for XP_009296759.1

    UniProtKB/TrEMBL
    A0A8M3AQ64
    Conserved Domains (5) summary
    cd11327
    Location:105 → 584
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:21 → 1533
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1074 → 1528
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:30 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:698 → 975
    hGDE_central; central domain of human glycogen debranching enzyme

  2. XM_005163617.4 → XP_005163674.1  glycogen debranching enzyme isoform X2

    UniProtKB/TrEMBL
    A0A8M2BAR0
    Conserved Domains (5) summary
    cd11327
    Location:105 → 584
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:21 → 1533
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1074 → 1528
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:30 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:698 → 975
    hGDE_central; central domain of human glycogen debranching enzyme

  3. XM_005163618.4 → XP_005163675.1  glycogen debranching enzyme isoform X1

    See identical proteins and their annotated locations for XP_005163675.1

    UniProtKB/TrEMBL
    A0A8M3AQ64
    Conserved Domains (5) summary
    cd11327
    Location:105 → 584
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:21 → 1533
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1074 → 1528
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:30 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:698 → 975
    hGDE_central; central domain of human glycogen debranching enzyme

  4. XM_009298485.4 → XP_009296760.1  glycogen debranching enzyme isoform X1

    See identical proteins and their annotated locations for XP_009296760.1

    UniProtKB/TrEMBL
    A0A8M3AQ64
    Conserved Domains (5) summary
    cd11327
    Location:105 → 584
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:21 → 1533
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1074 → 1528
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:30 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:698 → 975
    hGDE_central; central domain of human glycogen debranching enzyme

  5. XM_068224754.1 → XP_068080855.1  glycogen debranching enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8M3AQ64

  6. XM_009298483.4 → XP_009296758.1  glycogen debranching enzyme isoform X1

    See identical proteins and their annotated locations for XP_009296758.1

    UniProtKB/TrEMBL
    A0A8M3AQ64
    Conserved Domains (5) summary
    cd11327
    Location:105 → 584
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:21 → 1533
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1074 → 1528
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:30 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:698 → 975
    hGDE_central; central domain of human glycogen debranching enzyme
Nucleotide Protein
Heading Accession and Version

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