atr ATR serine/threonine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atrprovided by ZNC
Official Full Name: ATR serine/threonine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-458
See related: Ensembl:ENSDARG00000079625 AllianceGenome:ZFIN:ZDB-GENE-070912-458
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-231j24.1
Summary: Predicted to enable ATP binding activity; DNA binding activity; and protein serine/threonine kinase activity. Acts upstream of or within several processes, including determination of left/right symmetry; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of heart looping. Is expressed in hindbrain neural rod; midbrain neural rod; optic vesicle; somite; and tail bud. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (16384009..16449521, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (16715695..16780921, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of pancreatic left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart looping	IMP Inferred from Mutant Phenotype more info	PubMed

XP_696163.5

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The following sections contain reference sequences that belong to a specific genome build. Explain