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aebp1b AE binding protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 567630, updated on 9-Dec-2024

Summary

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Official Symbol
aebp1bprovided by ZNC
Official Full Name
AE binding protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8546
See related
Ensembl:ENSDARG00000006901 AllianceGenome:ZFIN:ZDB-GENE-030131-8546
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb14g01; wu:fb14g01; CH1073-459J12.1; si:ch1073-459j12.1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process; protein processing; and regulation of DNA-templated transcription. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome classic-like 2. Orthologous to human AEBP1 (AE binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See aebp1b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (44759567..44800691)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (44765655..44806787)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene steroidogenic acute regulatory protein Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1F subunit a Neighboring gene uncharacterized LOC103911563

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A single-cell transcriptome atlas for zebrafish development. Farnsworth DR, et al. Dev Biol, 2020 Mar 15. PMID 31782996, Free PMC Article
  2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inactive carboxypeptidase-like protein X2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    44759567..44800691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_690930.10 → XP_696022.6  inactive carboxypeptidase-like protein X2 isoform X1

    UniProtKB/TrEMBL
    A0A8N7TEF3, F1RAC0
    Related
    ENSDARP00000113570.1, ENSDART00000132115.2
    Conserved Domains (6) summary
    cd11308
    Location:1040 → 1115
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:403 → 556
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    smart00410
    Location:62 → 145
    IG_like; Immunoglobulin like
    cd00057
    Location:402 → 555
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:577 → 1036
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    cl11960
    Location:56 → 147
    Ig; Immunoglobulin domain

  2. XM_005167251.5 → XP_005167308.1  inactive carboxypeptidase-like protein X2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFA8
    Conserved Domains (6) summary
    cd11308
    Location:1039 → 1114
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:402 → 555
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    smart00410
    Location:62 → 145
    IG_like; Immunoglobulin like
    cd00057
    Location:401 → 554
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:576 → 1035
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    cl11960
    Location:56 → 147
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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