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mfn2 mitofusin 2 [ Danio rerio (zebrafish) ]

Gene ID: 567448, updated on 15-Dec-2024

Summary

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Official Symbol
mfn2provided by ZNC
Official Full Name
mitofusin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-081105-44
See related
Ensembl:ENSDARG00000079504 AllianceGenome:ZFIN:ZDB-GENE-081105-44
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mg:cb01g09; wu:fb79a11; si:dkeyp-104h9.2
Summary
Predicted to enable GTPase activity. Acts upstream of or within several processes, including axonal transport of mitochondrion; axonogenesis; and neuromuscular junction development. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including heart; muscle; nervous system; otic vesicle; and ventral mesenchyme. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See mfn2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (47897734..47948904)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (47908742..47959912)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-104h9.5 Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a Neighboring gene uncharacterized LOC108190986 Neighboring gene PR domain containing 16 Neighboring gene uncharacterized LOC137496386

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish. Chapman AL, et al. PLoS One, 2013. PMID 23840650, Free PMC Article
  2. Mitochondrial dynamics in mammalian health and disease. Liesa M, et al. Physiol Rev, 2009 Jul. PMID 19584314
  3. Developmental defects and neuromuscular alterations due to mitofusin 2 gene (MFN2) silencing in zebrafish: a new model for Charcot-Marie-Tooth type 2A neuropathy. Vettori A, et al. Neuromuscul Disord, 2011 Jan. PMID 20951042
  4. Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton. Zhou W, et al. J Cell Sci, 2020 Sep 4. PMID 32788232, Free PMC Article
  5. Opa1 is required for proper mitochondrial metabolism in early development. Rahn JJ, et al. PLoS One, 2013. PMID 23516612, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MFN2 mutation status should be investigated in patients presenting with early-onset recessively inherited axonal CMT
    Title: Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.
  2. These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo.
    Title: Developmental defects and neuromuscular alterations due to mitofusin 2 gene (MFN2) silencing in zebrafish: a new model for Charcot-Marie-Tooth type 2A neuropathy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axonal transport of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitofusin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128254.2 → NP_001121726.1  mitofusin-2

    See identical proteins and their annotated locations for NP_001121726.1

    Status: VALIDATED

    Source sequence(s)
    BX548250
    UniProtKB/TrEMBL
    A0A8M2BJP0, A8WIN6
    Related
    ENSDARP00000123285.2, ENSDART00000140266.3
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:594 → 754
    Fzo_mitofusin; fzo-like conserved region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    47897734..47948904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172484.5 → XP_005172541.1  mitofusin-2 isoform X1

    See identical proteins and their annotated locations for XP_005172541.1

    UniProtKB/TrEMBL
    A0A8M2BJP0, A8WIN6
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:594 → 754
    Fzo_mitofusin; fzo-like conserved region

  2. XM_005172483.5 → XP_005172540.1  mitofusin-2 isoform X1

    See identical proteins and their annotated locations for XP_005172540.1

    UniProtKB/TrEMBL
    A0A8M2BJP0, A8WIN6
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:594 → 754
    Fzo_mitofusin; fzo-like conserved region
Nucleotide Protein Strain
Heading Accession and Version

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