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wnk3 WNK lysine deficient protein kinase 3 [ Danio rerio (zebrafish) ]

Gene ID: 567408, updated on 4-Jan-2025

Summary

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Official Symbol
wnk3provided by ZNC
Official Full Name
WNK lysine deficient protein kinase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-090312-81
See related
AllianceGenome:ZFIN:ZDB-GENE-090312-81
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wnk3l; wnk3-like; im:7152756; si:dkey-151g10.3
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in Prieto syndrome. Orthologous to human WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See wnk3 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (25151153..25225747)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (25224395..25299200)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene erb-b2 receptor tyrosine kinase 3b Neighboring gene proliferation-associated 2G4, b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. Lai JG, et al. PLoS One, 2014. PMID 25171174, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase WNK3; serine/threonine-protein kinase WNK1
XP_009295201.2
XP_009295202.2
XP_009295203.2
XP_009295204.2
XP_021325641.1
XP_021325642.1
XP_021325643.1
XP_021325644.1
XP_021325645.1
XP_068075160.1
XP_695795.7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    25151153..25225747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469966.2 → XP_021325641.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PTI7
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  2. XM_021469967.2 → XP_021325642.1  serine/threonine-protein kinase WNK1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P5H4
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  3. XM_021469970.2 → XP_021325645.1  serine/threonine-protein kinase WNK3 isoform X5

    UniProtKB/TrEMBL
    A0A8M9PWV5
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  4. XM_021469968.2 → XP_021325643.1  serine/threonine-protein kinase WNK3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PFG8
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  5. XM_021469969.2 → XP_021325644.1  serine/threonine-protein kinase WNK1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PL63
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395152.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    52346..129233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296926.4 → XP_009295201.2  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AVG7
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  2. XM_690703.10 → XP_695795.7  serine/threonine-protein kinase WNK1 isoform X2

    UniProtKB/TrEMBL
    A0A8N7TFG0
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  3. XM_009296929.4 → XP_009295204.2  serine/threonine-protein kinase WNK3 isoform X5

    UniProtKB/TrEMBL
    A0A8M3ANR2
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  4. XM_009296927.4 → XP_009295202.2  serine/threonine-protein kinase WNK3 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AN04
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  5. XM_009296928.4 → XP_009295203.2  serine/threonine-protein kinase WNK1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B680
    Conserved Domains (2) summary
    cd14031
    Location:190 → 464
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:480 → 517
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  6. XM_068219059.1 → XP_068075160.1  serine/threonine-protein kinase WNK1 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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