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pld6 phospholipase D family, member 6 [ Danio rerio (zebrafish) ]

Gene ID: 567338, updated on 9-Dec-2024

Summary

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Official Symbol
pld6provided by ZNC
Official Full Name
phospholipase D family, member 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3825
See related
Ensembl:ENSDARG00000059951 AllianceGenome:ZFIN:ZDB-GENE-030131-3825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc55d08; wu:fc55d08; zgc:162591
Summary
Predicted to enable RNA endonuclease activity, producing 5'-phosphomonoesters; cardiolipin hydrolase activity; and protein homodimerization activity. Predicted to be involved in several processes, including germ cell development; mitochondrial fusion; and piRNA processing. Predicted to act upstream of or within cell differentiation; lipid catabolic process; and spermatogenesis. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human PLD6 (phospholipase D family member 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See pld6 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (52203015..52210546, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (51568890..51576421, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene bestrophin 2 Neighboring gene RAB3D, member RAS oncogene family, a Neighboring gene calponin 1, basic, smooth muscle, a Neighboring gene si:dkey-121b10.7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Rapid and Noninvasive Method That Extracts Polymerase Chain Reaction-Ready Genomic DNA from Adult Zebrafish. Jang JY, et al. Zebrafish, 2022 Aug. PMID 35877315, Free PMC Article
  2. A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Zhang R, et al. Adv Sci (Weinh), 2022 Dec. PMID 36257818, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA endonuclease activity, producing 5'-phosphomonoesters IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in P granule organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial cardiolipin hydrolase
Names
PLD 6
choline phosphatase 6
mitoPLD
mitochondrial phospholipase
phosphatidylcholine-hydrolyzing phospholipase D6
phospholipase D6
probable phospholipase D family member FLJ33580 homolog
NP_001082883.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089414.1 → NP_001082883.1  mitochondrial cardiolipin hydrolase

    See identical proteins and their annotated locations for NP_001082883.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134035
    UniProtKB/Swiss-Prot
    A3KNW0, B8A667
    Related
    ENSDARP00000078381.4, ENSDART00000083946.5
    Conserved Domains (2) summary
    cd09171
    Location:71 → 208
    PLDc_vPLD6_like; Catalytic domain of vertebrate phospholipase D6 and similar proteins
    pfam13091
    Location:84 → 208
    PLDc_2; PLD-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    52203015..52210546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KNW0.2 GenPept UniProtKB/Swiss-Prot:A3KNW0

Gene LinkOut

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