U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cnga3a cyclic nucleotide gated channel subunit alpha 3a [ Danio rerio (zebrafish) ]

Gene ID: 567242, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
cnga3aprovided by ZNC
Official Full Name
cyclic nucleotide gated channel subunit alpha 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090611-2
See related
Ensembl:ENSDARG00000070726 AllianceGenome:ZFIN:ZDB-GENE-090611-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable monoatomic ion channel activity. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Is expressed in brain; gonad; heart; and sensory system. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cnga3a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (38792546..38819044, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (38796397..38821512, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:dkey-29g22.2 Neighboring gene ubiquitin protein ligase E3A Neighboring gene serine/threonine kinase 35, like Neighboring gene uncharacterized LOC137495995

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a novel cyclic nucleotide-gated channel from zebrafish brain. Tetreault ML, et al. Biochem Biophys Res Commun, 2006 Sep 22. PMID 16887101
  2. Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin. Blechman J, et al. Front Cell Dev Biol, 2018. PMID 30294598, Free PMC Article
  3. Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish. Rozenblat R, et al. Int J Mol Sci, 2022 Feb 23. PMID 35269606, Free PMC Article
  4. Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors. Wang YY, et al. Gene, 2024 Mar 1. PMID 38043833
  5. Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Tang SL, et al. Front Genet, 2022. PMID 35991544, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cyclic nucleotide-gated channel cone photoreceptor subunit alpha
Names
cnga3
cyclic nucleotide gated channel alpha 3a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    38792546..38819044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477202.2 → XP_021332877.1  cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8M9PN18
    Related
    ENSDARP00000125099.1, ENSDART00000149833.3
    Conserved Domains (3) summary
    cd00038
    Location:496 → 612
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:182 → 424
    Ion_trans; Ion transport protein
    pfam16526
    Location:612 → 682
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

  2. XM_009302572.3 → XP_009300847.1  cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8M3ATJ7
    Related
    ENSDARP00000094899.5, ENSDART00000104124.5
    Conserved Domains (4) summary
    COG0664
    Location:448 → 570
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:454 → 570
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:171 → 382
    Ion_trans; Ion transport protein
    pfam16526
    Location:570 → 640
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

  3. XM_005166084.4 → XP_005166141.1  cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDH8
    Conserved Domains (4) summary
    COG0664
    Location:549 → 671
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:555 → 671
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:272 → 483
    Ion_trans; Ion transport protein
    pfam16526
    Location:671 → 741
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials