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pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 [ Danio rerio (zebrafish) ]

Gene ID: 567170, updated on 9-Dec-2024

Summary

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Official Symbol
pafah1b2provided by ZNC
Official Full Name
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-43
See related
Ensembl:ENSDARG00000035352 AllianceGenome:ZFIN:ZDB-GENE-060526-43
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-139a5.3
Summary
Predicted to enable platelet-activating factor acetyltransferase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See pafah1b2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (37963219..37973519)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37362966..37373366)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene sodium channel, voltage-gated, type IV, beta b Neighboring gene myelin protein zero-like 2b Neighboring gene apolipoprotein A-Ia Neighboring gene ring finger protein 214 Neighboring gene si:dkey-111e8.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-activating factor acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha2
NP_001076320.1
XP_005165401.1
XP_021331960.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082851.1 → NP_001076320.1  platelet-activating factor acetylhydrolase IB subunit alpha2

    See identical proteins and their annotated locations for NP_001076320.1

    Status: PROVISIONAL

    Source sequence(s)
    BX465852
    UniProtKB/TrEMBL
    A2BGB4, B1H1L2
    Related
    ENSDARP00000111226.2, ENSDART00000127648.3
    Conserved Domains (1) summary
    cd01820
    Location:7 → 202
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    37963219..37973519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165344.5 → XP_005165401.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    See identical proteins and their annotated locations for XP_005165401.1

    UniProtKB/TrEMBL
    A2BGB4, B1H1L2
    Conserved Domains (1) summary
    cd01820
    Location:7 → 202
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

  2. XM_021476285.2 → XP_021331960.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    UniProtKB/TrEMBL
    A2BGB4, B1H1L2
    Conserved Domains (1) summary
    cd01820
    Location:7 → 202
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394596.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    130048..134581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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